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Mechanism of SGLT2 inhibitors in improving immune imbalance in diabetic mice with sepsis via regulating macrophage M2 polarization through the APOC1/HMGB1/TLR4 axis.

Article D Peer reviewed Preclinical

Key takeaways

This study looked at mice with diabetes and a severe infection. It tested how a diabetes drug affects the immune system. The drug helped balance the immune response. This was done in animals, not people yet.

Who did this work

You T · Yang H · Chen G

Source

Article · PubMed, the drug frontier · 2026 Aug 29
https://pubmed.ncbi.nlm.nih.gov/42800003/