← brief for 2026-09-25 · Slowing decline

HIF-1α/ADPGK-driven glycolytic reprogramming provokes platelet hyperactivation by fueling RHOA lactylation.

Article D Peer reviewed Preclinical

Key takeaways

This study looked at how low oxygen levels make blood platelets too active. It found that a specific protein change drives this effect in people with kidney disease. The work was done in cells and animals, not in people yet. This helps explain why kidney disease raises the risk of blood clots.

Who did this work

Lan Q · Wang Y · Xie M · Xu B · Sun Y · Xin W · Qin S · Chen J · Gong S · Lv L · Xin Q · Xiong J

Source

Article · PubMed, CKD progression and prevention · 2026 Sep 25
https://pubmed.ncbi.nlm.nih.gov/42789456/