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Repurposing a prostate tumor marker: elevated FPSA/TPSA ratio as a novel non-invasive biomarker for declining eGFR in male type 2 diabetes

Paper C Peer reviewed Observational

Key takeaways

PSA is a blood test normally used to check the prostate. In men with type 2 diabetes, this study found that a higher ratio of free PSA to total PSA went along with a faster drop in kidney filtering rate (eGFR). That is a link, not proof that one causes the other. It would need checking in other groups of men before any doctor used it to flag kidney decline early.

Who did this work

Shihua Zhao (Central Hospital of Zibo) · Honglei Hu (Central Hospital of Zibo) · Xiaodong Zhao (Central Hospital of Zibo) · Lei Zhang (Diabetes & Endocrine Associates) · Deying Niu (Central Hospital of Zibo)

Source

Paper · OpenAlex, CKD works · 2026-09-11
https://doi.org/10.3389/fendo.2026.1905743