← brief for 2026-09-09 · Slowing decline

MORG1 Haploinsufficiency Is Associated with Stage- and Sex-Dependent Renoprotection and Signalling Alterations in Diabetic Kidney Disease

Key takeaways

Mice with only one working copy of a gene called MORG1 had less kidney damage from diabetes than normal mice. The protection depended on the stage of the disease and on whether the animal was male or female. This was done in animals, not people, so it does not yet tell anyone with kidney disease what to do.

Who did this work

Jonas Till Ihle (Jena University Hospital) · Luisa Duong (Jena University Hospital) · Nadja Ziller (Jena University Hospital) · Eric Jankowski (Jena University Hospital) · Karin Elflein (Jena University Hospital) · Alexander Berndt (Jena University Hospital) · Nikolaus Gaßler (Jena University Hospital) · Günter Wolf (Jena University Hospital) · Ivonne Loeffler (Jena University Hospital)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-09-08
https://doi.org/10.3390/ijms27187990