← brief for 2026-09-09 · Slowing decline
Irisin upregulation as a contributory mechanism for the therapeutic benefits of SGLT-2 inhibitors.
Key takeaways
This review argues that SGLT2 inhibitors, kidney-protective diabetes drugs, may work partly by raising irisin, a hormone that muscles release during exercise. The evidence behind that idea comes from lab and animal work, not from studies in people. It is a proposed explanation for benefits we already know these drugs have, so it does not change how anyone is treated. The exercise connection is interesting but this is a drug mechanism story, not a mind-body finding.
Who did this work
Noto NM (Department of Pharmaceutical Sciences, Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA. Electronic address: [email protected].) · Martin K (Department of Pharmaceutical Sciences, Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA. Electronic address: [email protected].) · Fidelia S (Department of Pharmaceutical Sciences, Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.) · Parmar MS (Department of Foundational Sciences, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Clearwater, FL 33759, USA. Electronic address: [email protected].) · Cubeddu LX (Department of Pharmaceutical Sciences, Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA. Electronic address: [email protected].) · Gurusamy N (Department of Pharmaceutical Sciences, Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA. Electronic address: [email protected].) · Speth RC (Department of Pharmaceutical Sciences, Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA; Department of Pharmacology and Physiology, School of Medicine, Georgetown University, Washington, DC 20057, USA. Electronic address: [email protected].)
Source
Paper · Europe PMC, CKD mind-body · 2026-07-29
https://doi.org/10.1016/j.pharmthera.2026.109090