← brief for 2026-09-09 · Slowing decline

IFN-γ–dominant immune shift is associated with reduced protective ILC2 responses in chronic kidney disease

Paper D Peer reviewed Preclinical

Key takeaways

In chronic kidney disease the immune system tilted toward one alarm signal called IFN-gamma. At the same time a protective immune cell type, called ILC2, responded less than it should. This was laboratory work on immune cells, not a treatment tested in people. It offers a possible reason kidney disease keeps inflammation going, and nothing more yet.

Who did this work

Yoshihiro Kuno (SHOWA Medical University) · Hiroki Ishikawa (SHOWA Medical University) · Ryuichi Nagashima (SHOWA Medical University) · Yasunari Matsuzaka (SHOWA Medical University) · Chikara Kohda (SHOWA Medical University) · Nobuhiro Kanazawa (SHOWA Medical University) · Taihei Suzuki (SHOWA Medical University) · Takeo Isozaki (SHOWA Medical University) · Hirotaka Kuwata (SHOWA Medical University) · Masayuki Iyoda (SHOWA Medical University)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-09-08
https://doi.org/10.3389/fimmu.2026.1870937