← brief for 2026-09-09 · Transplant & xeno

Hereditary thrombophilia due to a novel histidine-rich glycoprotein mutation leading to deferral of kidney transplantation: a case report.

Key takeaways

A 42-year-old woman on dialysis kept getting blood clots in her dialysis access, the vein or graft used to connect her to the machine. Standard clotting tests looked normal, but low antithrombin and a high D-dimer, both blood markers of clotting trouble, led doctors to test her genes. They found a new mutation in the HRG gene that causes an inherited tendency to clot, and her kidney transplant was put off because of it. This is one patient, so it shows a possible link between this mutation and clotting, not proof that the mutation caused it.

Who did this work

Lin M (Department of organ transplantation, the Third Affiliated Hospital of Guangzhou Medical University, Liwan District.) · Wang B (Department of organ transplantation, the Third Affiliated Hospital of Guangzhou Medical University, Liwan District.) · Wu Q (GuangZhou MED-MAX Medical Lab Co., Ltd; Huangpu District, Guangzhou, China.)

Source

Paper · Europe PMC, CKD · 2026-09-09
https://doi.org/10.1097/mbc.0000000000001452