← brief for 2026-09-09 · Nutrition & lifestyle

Gut microbiota and metabolomics reveal the combined effects of Alpinia oxyphylla fructus polysaccharide and nootkatone on chronic kidney disease via the “gut-kidney” axis

Paper D Peer reviewed Preclinical

Key takeaways

Researchers tested two compounds from a Chinese herb, a plant sugar and an oil called nootkatone, given together in chronic kidney disease. They tracked gut bacteria and body chemistry to see how the gut and the kidney talk to each other. This was lab and animal work, not people yet. It does not show the supplement is safe or helpful for humans.

Who did this work

Rong Zhang (Shenyang Fifth People Hospital) · Yangmei Chen (Hainan Medical University) · Haisen Meng (Hainan Medical University) · An Jia (Huanghe Science and Technology College) · Dingwen Fu (Hainan Medical University) · Xingzhou Lin (Hainan Medical University) · Jingzhe Wang (Hainan Medical University) · Jiajia He (Hainan Medical University) · Yue Zhou (Hainan Medical University) · Yonghui Li (Hainan Medical University)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-09-08
https://doi.org/10.3389/fphar.2026.1904155