← brief for 2026-09-09 · Slowing decline

Endocrine crosstalk in cardiovascular-kidney-metabolic syndrome-related heart failure: the fibroblast growth factor 23-Klotho axis and cardiometabolic therapy

Paper No results yet Peer reviewed

Key takeaways

This review looks at two body signals, FGF23 and Klotho, that fall out of balance when kidneys stop working well. The authors trace how that imbalance may strain the heart in people who have kidney, heart and metabolic disease together, and which drugs might act on it. It summarizes other people's research and reports no new patient results.

Who did this work

Dan Sun (Heilongjiang University of Chinese Medicine) · Xingjia Wang (Heilongjiang University of Chinese Medicine) · He Wang (First Affiliated Hospital of Heilongjiang University of Chinese Medicine) · Zhiyi Shen (Heilongjiang University of Chinese Medicine) · Xiangxu Meng (Heilongjiang University of Chinese Medicine) · Yabin Zhou (First Affiliated Hospital of Heilongjiang University of Chinese Medicine)

Source

Paper · OpenAlex, CKD works · 2026-09-08
https://doi.org/10.3389/fendo.2026.1933732