← brief for 2026-09-05 · Slowing decline

Tubule-Specific RGC-32 Knockout Exhibits Direct and Progressive Aggravating Activity Against Renal Function in an Ischemia–Reperfusion Mouse Model

Key takeaways

Scientists switched off a gene called RGC-32 in the filtering tubes of mouse kidneys, then briefly cut off and restored blood flow to injure them. Kidneys missing that gene did worse, and kept getting worse as time passed. That suggests the gene normally helps protect the kidney after an injury. This was in mice, not people, so it is early biology and not a treatment.

Who did this work

Yan Gong (Shanghai Children's Hospital) · Dan Feng (Shanghai Children's Hospital) · Jing Zhang (Shanghai Children's Hospital) · Mengying Li (Shanghai Children's Hospital) · Wenyan Huang (Shanghai Children's Hospital)

Source

Paper · OpenAlex, CKD works · 2026-09-04
https://doi.org/10.3390/biology15171535