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Autophagy and Mitophagy in Hypertensive Chronic Kidney Disease: Evidence Grading, Cell-Type Divergence, and a Working Lysosomal Hypothesis

Key takeaways

This paper reviews how kidney cells clear out their own damaged parts, a clean-up process called autophagy, and how they recycle worn-out power plants, called mitophagy. The authors argue that failing recycling bins inside the cell, the lysosomes, help drive kidney damage in people with high blood pressure. They sort the existing evidence by how strong it is and point out that different kidney cell types behave differently. It is a summary of other people's work plus a proposed idea, so there are no new results here.

Who did this work

Suyeon Han (Catholic University of Korea) · Yoon‐Kyung Chang (Catholic University of Korea) · Ji Yoon Jo (Chungnam National University) · Dae Eun Choi (Chungnam National University)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-09-04
https://doi.org/10.3390/life16091481