← brief for 2026-08-20 · Regeneration & devices

N-Alkylated Monoterpene Indole Alkaloid Derivatives as Chemotherapy Adjuvants That Overcome P-glycoprotein-Mediated Multidrug Resistance in Cancer Cells, Spheroids and Patient-Derived Colorectal Cancer Organoids.

Article D Peer reviewed Preclinical

Key takeaways

A study in mouse and human cancer organoids found that three drug derivatives overcome resistance to the chemotherapy drug doxorubicin. This is a preclinical study and not in humans yet.

Who did this work

Nejedlý T · Strnad O · Ulrych J · Hanžl V · Křížová I · Dobiasová S · Cardoso DP · Mulhovo SF · Častorálová M · Ferreira MU · Viktorová J

Source

Article · PubMed, organoids & devices · 2026 Aug 15
https://pubmed.ncbi.nlm.nih.gov/42621525/