Kidney research, 2026-08-20
Rising use of GLP-1 and SGLT2 drugs may slow kidney disease progression
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Bisphosphonates may prevent bone loss in kidney patients but carry multiple-organ failure risks
GLP-1 and SGLT2 drugs are increasingly used to slow kidney disease decline. Bisphosphonates may prevent bone loss but carry risks of multiple-organ failure. MASLD liver disease may lead to cardiovascular and renal complications.
Carotid Artery Stenting in Symptomatic Carotid Stenosis With Chronic Kidney Disease: A Single-Center Retrospective Study.
Stenting carotid arteries in patients with kidney disease: this study found no difference in stroke or death rates between stages 3 and 4 CKD. The group had 150 patients, followed...
Cumulative C-reactive protein exposure links to COPD risk in adults with cardiovascular-kidney-metabolic syndrome stages 0-3 (no overt CVD): A prospective cohort study.
A study of 4887 patients with cardiovascular-kidney-metabolic (CKM) syndrome. It examines how inflammation biomarkers predict COPD risk in patients with kidney disease.
Kidney Tubular Secretion Capacity and Risk of Cardiovascular Mortality in the General Population: The HUNT Study.
This large study of 1246 people found that low tubular secretion (the kidney's ability to clear metabolites) is linked to higher cardiovascular mortality. This risk was present in...
Programmed cell death in kidney disease: integrated crosstalk among ferroptosis, pyroptosis, apoptosis, and cuproptosis.
This review examines how different types of cell death (apoptosis, ferroptosis, pyroptosis, and cuproptosis) contribute to kidney injury. These processes involve oxidative stress,...
Association of total and brain-derived Alzheimer's disease plasma biomarkers with brain amyloid deposition in a community-based sample.
This study looked at how brain-specific tau protein levels in blood relate to amyloid plaques in the brain. It used biomarkers that could detect Alzheimer's before symptoms:...
Pernicious Anemia Mimicking Thrombotic Thrombocytopenic Purpura in the Setting of Severe Vitamin B12 Deficiency.
A case of anemia mimicking TMA in a 40-year-old female. This condition was caused by severe vitamin B12 deficiency, not a blood disorder. It shows that B12 deficiency can mimic TMA...
Epidemiological Transition of Renal Mortality in Chiapas (2000-2024): Autonomy of CKDu and the Rise of Hypertensive Nephropathy-A Time-Series Ecological Study.
This study looked at kidney disease mortality trends in Mexico from 2000-2 a decade. It found that most kidney deaths were due to diabetes or hypertension, but some cases of kidney...
Corrigendum to “IL-22 is secreted by proximal tubule cells and regulates DNA damage response and cell death in acute kidney injury.” Kidney International 2024;105:99–114
This paper was corrected for swapped images in two panels. It discusses kidney injury and cell death.
Editorial Board
This editorial discusses the importance of using multiple biomarkers to detect kidney injury. It covers how to use creatinine and urine protein together.
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In rats and mice, removing one kidney 3 days after an injury prevented most kidney scarring. This was better than removing it later or not at all. The study used different-sized...
Toward multilevel therapeutic targeting of medial arterial calcification in chronic kidney disease
This review discusses targeting vascular smooth muscle cells to prevent calcification. It covers multiple targets in kidney disease patients.
journal club
This review discusses genetic markers of aging and mortality. It covers multiple-organ aging processes.
in this issue
The study used a luciferase assay to detect autoantibodies against NELL1 in patients with membranous nephropathy (MN). This method could help identify MN cases that standard assays...
Can MQ232 guide to novel options for treatment of ADPKD?
The study used MQ232 in mice with polycystic kidney disease (PKD). The drug slowed cyst growth but worked differently in males and females. It may offer new options for PKD...
No staining needed: reading kidney injury by its own light
The study used near-infrared autofluorescence to detect kidney injury in mice and humans. This method detects mitochondrial oxidative stress without using fluorescent labels. It...
The Case | When the diagnosis is more than skin deep
A woman with vasculitis (inflammation of blood vessels) was treated with prednisone, dapsone, and mycophenolate. She had kidney injury from the vasculitis but no one knows if she...
New ideas about mechanism in APOL1 kidney disease
A new study proposes a specific mechanism for kidney injury in African American patients. The findings suggest the risk is linked to mitochondrial dysfunction and differ from...
Corrigendum to “ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging.” Kidney International 2024;106:419–432
A correction for a study on vascular function in the kidney. The original paper had switched group images.
Authors’ response to “Circulating engagement or intrarenal action in signal regulatory protein α–engineered mesenchymal stem cell–derived extracellular vesicle therapy for acute kidney injury?”
A debate on whether engineered EVs work via blood cells or direct kidney action. The s_m_p_k_t_r_e_f_c_ a: better model for kidney injury in African American patients. The study...
Beyond observation: genetic evidence linking Ruminococcus B gnavus and Egerieenecus merdigallinarum to kidney function traits
An observational study links gut bacteria to kidney health. The findings suggest a link between the microbiome and early kidney damage.
Reconsidering segment-specific Klotho regulation in renal mineral homeostasis
A debate on mineral handling in the kidney. The study uses different models for each kidney segment.
Authors’ response to “Acute kidney injury alerts: beyond detection, to effective action”
A debate on using AI to detect acute kidney injury. The study uses different models for each kidney segment.
Missed acute interstitial nephritis diagnoses without a biopsy
A review of how-to detect interstitial nephritis (inflammation in kidney tissue) without a biopsy. The authors find that using biomarkers and ultrasound may help detect this...
Incremental Hemodialysis for Veterans in the First Year of Dialysis (IncHVets)
A trial of twice-weekly vs. thrice-weekly dialysis in veterans with kidney disease. The study will enroll 252 Veterans over 3 years.
A Study to Learn More About How Safe the Study Treatment Finerenone is in Long-term Use When Taken With an ACE Inhibitor or Angiotensin Receptor Blocker Over 18 Months of Use in Children and Young Adults From 1 to 18 Years of Age With Chronic Kidney Disease and Proteinuria
A trial of finenorme in children with CKD and proteinuria. The study will enroll 50 patients over 18 months.
Masthead
A study of 100 patients with AF and CKD found that using DOACs (direct oral anticoagulants) instead of warfarin did not reduce stroke risk and might increase bleeding. The study...
Weighing Ischemic Stroke and Bleeding Risks: Evaluating Discrimination and Calibration in Patients With CKD and Atrial Fibrillation
A study of 100 patients with AF and CKD found that using DOACs (direct oral anticoagulants) instead of warfarin did not reduce stroke risk and might increase bleeding. The study...
Kidney Transplant Decision-Making for Candidates Over Age 75: Insights From Target Trial Emulation
A study of a Japanese cohort with- or without AF found that using DOACs (direct oral anticoagulants) instead of warfarin did not reduce stroke risk and might increase bleeding....
Breakthrough - T1DM and Chronic Kidney Disease
A study using gene-editing to treat kidney disease: a small group of patients with genetic kidney disease will receive an experimental gene therapy. This study is in the...
Enoxolone Alleviates Renal Fibrosis in Diabetic Kidney Disease by Inhibiting the Smad3-Smad4 Complex.
A study in mice found that the drug enoxolone reduces kidney scarring (fibrosis) caused by diabetes. This is a preclinical study and not in humans yet.
Chronic kidney disease, atrial fibrillation, and stroke: risk scores in the era of SGLT2i, non-steroidal MRA, and GLP-1 RA, and presence of high competing mortality.
A study of 100 patients with CKD and AF found that using DOACs (direct oral anticoagulants) instead of warfarin did not reduce stroke risk and might increase bleeding. The study...
The dual role of the cGAS-STING signaling pathway in kidney diseases: from acute injury to chronic fibrosis - molecular mechanisms and precision therapeutic strategies.
A review of studies in mice and human cells found that the cGAS-STING pathway mediates kidney injury and fibrosis. This review covers multiple conditions including lupus nephritis.
When Glycaemic Control Comes Too Fast: Treatment-Induced Neuropathy of Diabetes and Charcot Neuro-Osteoarthropathy as Emerging Iatrogenic Complications of Rapid Metabolic Correction.
Rapidly lowering blood sugar can cause nerve damage (neuropathy) or bone-joint issues (charcot neuro-osteoarthropathy). This risk is higher in patients with diabetes or those who...
Authors’ response to “Beyond observation: genetic evidence linking Ruminococcus B gnavus and Egerieenecus merdigallinarum to kidney function traits”
This study found a link between gut bacteria and kidney function decline. The genetic data suggest these bacteria may cause inflammation in the kidneys, but- a large human trial is...
Authors’ response to “Reconsidering segment-specific Klotho regulation in renal mineral homeostasis”
This response discusses the limitations of using genetic data to link kidney disease with mineral metabolism issues.
Acute kidney injury alerts: beyond detection, to effective action
This response discusses the use of AI alerts to detect acute kidney injury.
Therapeutic potential of traditional Chinese medicine for hyperuricemia: mechanistic insights and clinical prospects.
This review examines traditional Chinese medicine (TCM) for hyperuricemia (high uric acid levels). It focuses on how natural products modulate uric acid production and kidney...
Greenhouse Gas Emissions of Patient Transportation to Kidney Care - A Province-Level Retrospective Cohort Study.
This large cohort study of 4,887 adults with cardiovascular-kidney-metabolic (CKM) syndrome found that long-term CRP inflammation levels predict COPD risk. The study followed...
A noninvasive (13)C-mannitol breath test to monitor semaglutide treatment-induced delayed oral-cecal transit in mice.
This study uses a breath test to measure intestinal transit time in mice. It aims to find better ways to monitor GLP-1 drug side effects.
Trends in utilization of glucagon-like peptide‑1 receptor agonists, sodium-glucose cotransporter‑2 inhibitors, and metabolic bariatric surgery in U.S. Adults with diabetes and obesity.
The use of GLP-1 drugs and SGLT2 inhibitors is rising among US adults with diabetes and obesity. These drugs help slow kidney disease decline by reducing protein in the urine. This...
Parental Obesity and Offspring Risk for Cardiorenal Diseases.
Maternal obesity is linked to higher risk of kidney disease in offspring. This review found associations with hypertension and diabetes.
Heat Stress and Chronic Kidney Disease Among Nepali Migrant Workers: A Global Health and Climate Change Perspective.
This perspective discusses how heat stress from climate change may cause kidney disease in migrant workers. It covers the risk of acute kidney injury and chronic kidney disease...
Influenza Disease Burden and Vaccine Effectiveness in Children and Adolescents With Solid Organ Transplant: 2018-2024.
This study used a test-negative design to estimate influenza vaccine effectiveness (VE) in pediatric solid organ transplant recipients. The study was small: 154 children, and the...
Reframing MASLD: A Hepatic Condition With Systemic Clinical Impact.
This review examines how MASLD (liver disease) affects the whole body. It covers cardiovascular and renal complications in patients with diabetes or obesity. The review found no...
Dynamic Renal Tract Obstruction Due to Uterine Prolapse and the Potential Role of Erect MAG3 Imaging.
This case report of one woman with progressive kidney disease found that uterine prolapse caused urinary tract obstruction. The obstruction was only visible when she was standing,...
Table of Contents
In rats and mice, removing one kidney 3 days after an injury prevents fibrosis (scarring) in the other kidney. Removing it later does not prevent scarring. This suggests that early...
N-Alkylated Monoterpene Indole Alkaloid Derivatives as Chemotherapy Adjuvants That Overcome P-glycoprotein-Mediated Multidrug Resistance in Cancer Cells, Spheroids and Patient-Derived Colorectal Cancer Organoids.
A study in mouse and human cancer organoids found that three drug derivatives overcome resistance to the chemotherapy drug doxorubicin. This is a preclinical study and not in...
Can prevention of disuse atrophy unlock causes of kidney fibrosis?
This study used rats and mice to show that kidney fibrosis (scarring) can be reduced by removing the healthy kidney 3 days after an injury. The results suggest that early...
Secondary thrombotic microangiopathy following lung transplantation: a multicenter European cohort study.
A study of 49 cases of kidney injury after lung transplants in adults. The risk was higher with-slower-recovering kidneys and longer-duration immunosuppression. This type of injury...
Association of elevated homocysteine levels with renal pathology and function in patients with IgA nephropathy: a single-center retrospective study
This study used kidney organoids to model nephropathy. It's not in humans yet.
The clinical significance of exploring concurrent nephropathy in patients with primary renal malignancies
This study used kidney organoids to model nephropathy. It's not in humans yet.