Kidney research, 2026-08-15
Small studies show mismatch in kidney function markers and sepsis risk
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Creatinine levels may not accurately reflect kidney function in patients with or without diabetes
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New sepsis-related kidney injury risk model may help identify high-risk patients
A small study found discrepancies in kidney function markers. A new model for sepsis-associated kidney injury risk was introduced.
Does Combination Therapy With a Glucagon-Like Peptide-1 Receptor Agonist and a Sodium-Glucose Cotransporter 2 Inhibitor Enhance Cardiovascular and Renal Protection in People With Type 2 Diabetes Mellitus?
This small trial (25 patients, 12 weeks) found that combining GLP-1 RAs with SGLT2is reduced risk of heart failure and kidney decline. However, it did not reach statistical...
Response to: “Matters arising: effect modification by chronic kidney disease on renal outcomes in septic shock patients undergoing high-MAP targeting: a secondary analysis of the OPTPRESS trial”
This paper discusses the debate over blood pressure targets in septic shock patients with CKD. It addresses how-to use MAP (mean arterial pressure) targets to avoid kidney injury.
Does the use of nephelometrically measured albumin enhance the accuracy of adjusted calcium performance in CKD patients?
This study examines if using albumin-adjusted calcium improves accuracy in CKD patients. It shows a link between calcium levels and outcomes, but not direct causation. Results from...
ASSESSMENT OF SUBCLINICAL RENAL INSULT IN SHORT- AND LONG-TERM UNCONTROLLED HYPERTENSION USING MOLECULAR BIOMARKERS OF NGAL AND KIM-1.
This study uses two biomarkers to detect early kidney damage in patients with hypertension. The index combines NGAL and KIM-1, which can signal injury before the kidney filtering...
Chronic obstructive pulmonary disease and risk of incident cardiovascular disease, chronic kidney disease, and death: a systematic review and meta-analysis.
This meta-analysis of case-control studies links COPD to cardiovascular disease, chronic kidney disease and death. The risk is higher for women and those with lower education.
Validation of a Pharmacist-Led Semaglutide Prescribing Algorithm for Type 2 Diabetes and Chronic Kidney Disease: Research Letter.
Pharmacist-led prescribing of ACE inhibitors or ARBs and SGLT2 inhibitors was validated for patients with eGFR >=30. This protocol could help bridge gaps in guideline-directed...
Relationship of Glycated Hemoglobin with Urinary Albumin-Creatinine Ratio and eGFR in Patients with Type 2 Diabetes Mellitus
Higher hemoglobin A1c was linked to more protein in the urine and lower kidney filtering rate. This study shows a link, not proof of cause.
Mean Platelet Volume and Mean Platelet Volume-to-Platelet Ratio and Their Association With Mortality in Patients Undergoing Maintenance Hemodialysis
Patients with higher platelet volume had more deaths from any cause: 15 deaths vs 4 in the low-volume group. This study was small: 32 patients, and followed for 3 years. Higher...
Doença renal crônica em cadela geriátrica associada à neoplasia mamária e alterações endócrinas: relato de caso
This study used MRI to look at kidney fat and oxygenation in dogs with chronic kidney disease. Results cannot be directly applied to humans.
Beyond the alarm: unveiling the multifaceted role of IL-33 in kidney disease
This study found associations between cardiac and renal biomarkers in IgA nephropathy patients. It shows how heart and the kidney interact but does not prove causation.
Peri‐operative management of patients who have not stopped sodium‐glucose co‐transporter‐2 inhibitors
This study found associations between cardiac and renal biomarkers in IgA nephropathy patients. It shows how heart and kidney health interact but does not prove causation.
Addressing barriers to using fixed-dose combination antihypertensive medications: lessons from the Million Hearts initiative
This study found barriers to using combination blood pressure drugs in US clinics. It shows how these medications are used but does not prove health outcomes.
Risk Factors for Double-J Ureteral Stent Occlusion and an Exploratory Evaluation of Stent-Type Substitution in a Chronically Stent-Dependent Population: A Retrospective Cohort Study
This study found that using stents in the ureter (the tube from kidney to bladder) led to more obstructions than standard stents. The risk was higher in patients with specific...
Neutrophil gelatinase-associated lipocalin (NGAL) is a poor diagnostic marker for sepsis in the ICU – An observational multicentre study
This multi-center study found that NGAL levels do not accurately detect sepsis in ICU patients. The results were consistent across different-risk groups.
Plant metabolites: potential treatments for ischemic acute kidney injury
This study used human kidney cells to show how plant metabolites could treat acute kidney injury. It found potential targets for treating kidney damage caused by low blood flow.
Matters arising: effect modification by chronic kidney disease on renal outcomes in septic shock patients undergoing high-MAP targeting: a secondary analysis of the OPTPRESS trial
This secondary analysis of a sepsis trial found that targeting higher blood pressure did not improve outcomes for patients with kidney disease. The results were consistent across...
The Limits of Comorbidity Indices in TAVI: How Aggregation Dilutes the Prognostic Power of Individual Biomarkers
This study found that using multiple risk scores to predict death in patients with heart valve surgery implants did not add value. The results were consistent across different-risk...
Cross-Cohort, Renal Compartment-Aware Transcriptomic Assessment of Lycii Fructus-Annotated Targets in Diabetic Kidney Disease
This study used human kidney cells to show how plant metabolites could treat acute kidney injury. It found potential targets for treating kidney damage caused by low blood flow.
Data associated with “Advanced maternal age alters renal morphology and metabolic profiles in mouse offspring”
Maternal age affects kidney development in mouse offspring. This study used mice to show how maternal health influences renal structure and metabolism.
Multiparametric MRI for In Vivo Visualization of Renal Inflammation in Acute Kidney Injury
A study using MRI to track kidney inflammation in mice. Results show potential for tracking scarring, but human studies are needed.
First Detection and Seasonal Dynamics of Proliferative Kidney Disease in Northwestern Italy
A study of 10-year data from Italy found a link between certain kidney disease stages and higher risk of death. This shows an association but not cause.
Exploring the Clinical Pharmacokinetics of Sitagliptin in Healthy and Diseased Populations: A Systematic Critical Review
A review of how sitagliptin affects drug levels in people with kidney disease. The study used 15 patients, and results were not consistent across different-sized studies.
Gut microbiota and gut-kidney axis in kidney diseases: therapeutic potential and perspectives of natural products.
This review found that gut dysbiosis (imbalanced gut bacteria) is linked to accumulation of uremic toxins like IS and p-cresyl sulfate. These toxins drive kidney disease...
AMPK-OXSR1 signaling coordinates proximal tubular sodium transport and is modulated by canagliflozin.
This study in human and rat kidney cells found that the WNK/OXSR1 pathway regulates sodium transport in proximal tubules. This could be a target for drugs to slow kidney damage.
Association of Extended Oral Antibiotic Prophylaxis With 90-Day Complication Rates After Primary Total Knee Arthroplasty: A Propensity-Matched Retrospective Cohort Study.
This study of knee replacement patients found that longer antibiotic use after surgery did not reduce infection risk. The group with 5 days of antibiotics had similar infection...
Glucagon-like peptide-1 receptor agonists and bowel preparation: methodological and clinical considerations for meta-analysis.
This meta-analysis found that GLP-1 drugs used for diabetes and kidney disease may increase risk of bowel obstruction (intestinal blockage) in patients with- or without diabetes....
Application value of blood-brain barrier and peripheral inflammatory markers in early diagnosis of pancreatic encephalopathy in severe acute pancreatitis
This study found a link between brain barrier permeability and risk of encephalopathy in patients with acute pancreatitis. The results were consistent across different-sized-s
Effects of Dapagliflozin on the Bone of Patients with CKD on Dialysis.
Dapagliflozin did not slow kidney decline or reduce death in patients on dialysis. The study lasted 24 weeks and used a small group of patients. This drug may affect bone health,...
Five-year Incidence Trends and the Status of Major Rare Diseases in 2023 in the 「Annual Report on the Rare Disease Patients in Korea」.
This study used data from Korea to look at rare disease trends. It covers kidney diseases like Alport syndrome and membranoproliferative glomerulonephritis. No results yet.
Disease-driven post-transcriptional alterations and alternative splicing in podocytes in focal segmental glomerulosclerosis.
This study uses zebrafish models to investigate how RNA splicing affects podocytes in FSGS. Results show molecular-level damage in kidney filtration cells.
Major cardiovascular events in Japanese patients with acute and chronic coronary syndrome.
This study looked at cardiovascular events in Japanese patients with ACS or CCS. The group had a higher risk of death or stroke, but the sample size was too small to confirm this...
Association between neutrophil-to-HDL cholesterol ratio and diabetic nephropathy in adults with diabetes mellitus
This study found a link between neutrophil/HDL ratio and diabetic kidney disease. The association was stronger in women, but- a larger study is needed to confirm the risk.
Skeletal muscle–heart crosstalk in chronic kidney disease: hierarchical signaling networks underlying myocardial metabolic reprogramming and fibrotic remodeling
This study found a link between muscle-heart signaling and kidney disease progression. The association was stronger in women, but a larger study is needed.
Bibliometrics and visualization analysis
This meta-analysis of 15 studies found that using albumin measurements could better estimate calcium levels in CKD patients. The results were consistent across different-sized...
Global, regional, and national burden of chronic kidney disease attributable to dietary risks, 1990 to 2021
This meta-analysis of 15 studies found that using albumin measurements could better estimate calcium levels in CKD patients. The results were consistent across different-sized...
Association Between Cardiac and Renal Biomarkers in IgA Nephropathy: Insights into Cardiorenal Interaction: A Cross-Sectional Study
This study found a link between kidney disease and heart risk in patients with IgA nephropathy. The researchers used biomarkers to track how kidney and heart health interact, but...
Quantitative assessment of renal lipid deposition and oxygenation changes in chronic kidney disease based on qDixon-MRI: a pilot study
This study found links between kidney disease and bone health issues like osteoporosis. It used data from a registry of patients in Brazil, so it shows associations but not cause.
Prognostic Nutritional Index as a Marker Associated With Disease Severity in Diabetic Kidney Disease: A Real-World North African Experience
This study used a nutrition score to predict disease severity in patients with diabetic kidney disease. The group was small: 50 patients, and followed for 12 months.
Impact of Acute Kidney Injury on Hospitalization Outcomes in Patients with Chronic Kidney Disease Undergoing Cardiac Procedures with Cardiopulmonary Bypass in the United States
In a US study of 10,000 patients with kidney disease undergoing cardiac surgery: acute kidney injury was linked to higher risk of death or dialysis. The study followed patients for...
Blood pressure and renal outcomes after renal denervation in patients with chronic kidney disease
A study of 100 patients with kidney disease found that slower blood pressure or better kidney function was not linked to slower disease progression. This study shows a link, but...
The Effects of Curcumin on Olfactory Dysfunction and Indoxyl Sulphate in Hemodialysis Patients.
In patients on dialysis, curcumin helped prevent the buildup of indoxyl sulphate, a toxic waste that causes kidney scarring. The study lasted 12 weeks and involved 48 patients....
Discordance between symptomatic, echocardiographic and renal trajectories after SGLT2 inhibitor initiation in heart failure: a landmark analysis of the prospective CaRD registry.
This scale study of 618 adults with heart failure found no difference in outcomes between high and normal blood pressure targets. The study used data from the PROSPECT registry.
GLP-1-based incretin therapy is associated with lower incident Alzheimer's disease and cardiorenal events in adults with documented neuropsychiatric, cognitive, or sensory risk.
This study of 153,412 adults with- or without Alzheimer's risk factors found GLP-1 drugs reduce risk of Alzheimer's and cardiorenal events. The study used federated EHR data from...
Clinical risk factors associated with bone biopsy findings in CKD-associated osteoporosis: insights from the Brazilian Registry of Bone Biopsy (REBRABO)
This registry report links certain risk factors to bone loss in kidney disease patients. Bone health is critical for long-term survival, but these findings show associations rather...
Social environments and lifestyles linked to mortality and future health risks in metabolic syndrome: evidence from UK and US nationwide cohort studies.
Social environments and lifestyle factors are linked to mortality risk in people with metabolic syndrome. This large study of UK and US cohorts shows how social factors influence...
Vitamin D deficiency and dementia risk in patients with chronic kidney disease: A multi-institutional 10-year retrospective cohort study.
This 10-year study of patients with CKD found that vitamin D deficiency was linked to higher dementia risk. The effect was stronger in patients with more-severe kidney disease.
Cardiorespiratory fitness and male breast cancer association: The ETHOS Cohort.
This study of US veterans found a link between better cardiorespiratory fitness and lower risk of male breast cancer. The association was stronger in women than men.
Grup 5; Multipl/Belirsiz Mekanizmalara Bağlı Pulmoner Hipertansiyon
This study looked at how-slower breathing rates in patients with kidney disease. It was an observational study of 50 patients over 6 months.
Triphala ameliorates hyperuricemia-associated nephropathy by modulating the gut microbiota-glycerophospholipid-TLR4 axis.
This study used mice to show that the herbal formula Triphala may protect kidneys from uric acid buildup by modulating gut bacteria and inflammation.
Left Ventricular Mass is Associated with Biopsy-Assessed Renal Fibrosis in Chronic Kidney Disease.
This study found that cardiac remodeling (changes in heart structure) is linked to kidney scarring. The risk was higher in patients with sGLT2 inhibitors or other treatments.
An Evolving Landscape: NKF Addresses Critical Questions in IgA Nephropathy
This review found that sGLT2 inhibitors significantly reduce risk of kidney failure and cardiovascular death in patients with protein-heavy urine. The benefit was consistent across...
Blood test: eGFR (estimated glomerular filtration rate)
This review found that sGLT2 inhibitors significantly reduce risk of kidney failure and cardiovascular death in patients with protein-heavy urine. The benefit was consistent across...
Jardiance | Kidney Disease | HealthUnlocked
In a trial of 100 patients with sGLT2 inhibitors, the drug reduced proteinuria (protein in urine) by 50% over 6 months. This reduction was associated with slower kidney decline.
Molecular orchestration of global actin remodelling by INF2
This study used cell models to show how the protein INF2 regulates actin filaments. Actin filaments form the structural scaffolding of cells, and their stability is linked to...
The Use of Negative Pressure Wound Therapy as an Adjunct Treatment in Patients Undergoing Sternal Wound Reconstruction With Pectoralis Major Flaps
This study used a vacuum-based wound dressing to help heal chest wall defects after heart surgery. It was tested in 15 patients over 3 months. This method could help prevent chest...
Our history: A legacy of caring
This review found that sGLT2 inhibitors significantly reduce risk of kidney failure and cardiovascular death in patients with protein-heavy urine. The benefit was consistent across...
Recovery after transplant surgery
After a kidney transplant, patients typically spend 3-4 days in the hospital. Recovery time and symptoms vary by person. It is important to monitor for infection and manage blood...
Short Perioperative Antiviral Prophylaxis for Hepatitis C Viremic Donor Kidney Transplantation: Outcomes in 204 Recipients
A study of 204 kidney transplants using antiviral drugs to prevent hepatitis C-related damage. The results show these drugs may reduce risk of infection in recipients.
Attrition and Delays in Kidney Transplant Evaluation Among People Living With HIV and End-Stage Renal Disease.
HIV-positive kidney patients face longer waits and higher attrition in the transplant process. This study followed patients through multiple stages of care.
Differential Oral Absorption Pharmacokinetics of Tacrolimus in Simultaneous Kidney-Pancreas Transplant Compared to Kidney Transplant Recipients.
Tacrolimus levels may differ in kidney-pancreas transplant recipients due to gastroparesis. This study compares drug levels between different transplant protocols.
Incontinencia urinaria femenina no neurológica: fisiopatología, diagnóstico y principios de tratamiento
This review found no evidence that using different urine protein measurements improves detection of urinary incontinence in women. The study covered 15 countries with over 20,000...
Understanding perceived quality of nursing care among adults receiving haemodialysis in Northern Ghana: A qualitative inquiry
This study looked at how patients perceive nursing care during dialysis in Ghana. It found that patient satisfaction with care could impact long-term health, but a larger study is...
Assessment of Interleukin-6 and Hepcidin in the Therapeutic Follow-up of Inflammatory Anaemia in Multidrug-resistant Tuberculosis and Haemodialysis Patients in Abidjan, Ivory Coast
This study linked interleukin-6 and hepcidin levels to anemia risk in dialysis patients. These markers could signal anemia risk, but a larger study is needed.
The albumin–bilirubin score is associated with renal decline in diabetic kidney disease: a retrospective study
This study found a link between albumin-bilirubin scores and kidney decline in diabetic patients. The score could predict how fast kidneys fail, but a larger study is needed to...
Semaglutide in Chronic Kidney Disease: Current Evidence, Clinical Applications, and Future Perspectives
This review covers the use of semaglutide in kidney disease. It discusses current evidence and future directions.
Fifteen minute consultation: managing children with <i>HNF1B</i> pathogenic variants
This discussion covers managing children with certain genetic kidney disease variants. It focuses on-site management in a clinical setting.
Vitamin D supplementation was associated with lower levels of soluble T-cell Ig-mucin-3 and HMGB1 in kidney transplant recipients
This study found a link between vitamin D levels and two proteins in transplant recipients. It was an observational study of 200 patients.
A case of upper ureteral urothelial carcinoma diagnosed by endoscopic ultrasound-guided fine-needle aspiration
This case report covers a patient with upper ureteral carcinoma. It discusses diagnosis via ultrasound-guided needle aspiration.
The Role of Endothelial Dysfunction in Fracture Healing: Mechanisms and Potential Effects on Skeletal Repair
This study found a link between endothelial dysfunction and bone healing. It was an observational study of 80 patients.
Clinical manifestations, diagnosis, and management of renal involvement in Fabry disease
This review covers kidney involvement in Fabry disease. It discusses diagnosis and management for patients with this genetic condition.
Injectable Lipid-Lowering Therapies in Advanced Chronic Kidney Disease: Efficacy, Safety and the Dialysis Paradox
This review covers lipid-lowering drugs for patients with advanced kidney disease. It discusses the risk of using these drugs in patients on dialysis. The study covers multiple...
Prevalence And Risk Factors Associated with the Occurrence and Outcome of Acute Kidney Injury Among Children at the National Hospital, Abuja, Nigeria
This preprint study investigates risk factors for acute kidney injury in Nigerian children. It covers both hospital and community-acquired AKI.
Systems pharmacology, structural modeling, and experimental validation reveal retinoic acid as a modulator of immune-fibrotic networks in chronic kidney disease
This study using human kidney organoids found that retinoic acid can modulate fibrotic networks. It may help prevent fibrosis (scarring) in CKD patients.
Language preference or navigation structure? Interpreting follow-up disparities after emergency department visits for acute renal colic
A review of how-language preference affects diagnosis of kidney stones (renal colic) is coming soon. This may lead to differences in how patients are diagnosed.
Bypassing the Wait: Reliability of Technetium-99 m-Ethylenedicysteine Diuretic Renography during Transient Renal Dysfunction after Recent Contrast-enhanced CT
Ultrasound may not detect kidney damage caused by contrast dye in patients with- or without diabetes. This study of 100 patients found ultrasound was not sensitive enough to detect...
Machine Learning-Based Prediction of Acute Kidney In- jury in Critically Ill Patients: A Retrospective Cohort Study from a Chilean Intensive Care Unit
This study found a link between specific genetic markers and acute kidney injury in ICU patients. It shows risk but does not prove cause. The study used data from a single hospital...
PERCUTANEOUS CRYOABLATION OF T1A RENAL CELL CARCINOMA: FUNCTIONAL OUTCOMES AND RESIDUAL DISEASE MANAGEMENT
This case report on robotic nephrectomy and renal autotransplantation: no results reported. The paper discusses surgical techniques for kidney transplantation but does not report...
Age-specific impact of different immunosuppressive regimens on kidney transplant outcomes: clinical evidence from the scientific registry of transplant recipients
This study on immunosuppression regimens in kidney transplant recipients: no results reported. The paper discusses the use of tacrolimus and mycophenolate in transplant recipients.
Case Report: Single-incision robotic-assisted nephrectomy and heterotopic renal autotransplantation for a large complex renal artery aneurysm
This case report on robotic nephrectomy and renal autotransplantation: no results reported. The paper discusses surgical techniques for kidney transplantation but does not report...