← brief for 2026-08-13 · Slowing decline

Targeted inhibition of gut microbial trimethylamine-N oxide production fosters regression of chronic kidney disease phenotypes

Paper D Not peer reviewed Preclinical

Key takeaways

This study in human kidney cells found that targeting gut bacteria could slow kidney decline. It has not been tested in humans yet.

Who did this work

Joseph A. DiDonato (Cleveland Clinic) · Taylor L. Weeks (Cleveland Clinic) · Nilaksh Gupta (Cleveland Clinic) · Deepthi P. Mallela (Cleveland Clinic) · Jennifer A. Buffa (Cleveland Clinic) · Zeneng Wang (Cleveland Clinic) · Xinmin S. Li (Cleveland Clinic) · James T. Anderson (Cleveland Clinic) · Xiaoming Fu (Cleveland Clinic) · Naseer Sangwan (Cleveland Clinic) · Ina Nemet (Cleveland Clinic) · Scott J. Cameron (Cleveland Clinic)

Source

Paper · OpenAlex, CKD works · 2026-08-11
https://doi.org/10.5281/zenodo.17956371