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Semaglutide/Acarbose combination protects against diabetic nephropathy in rats; a novel insight into modulation of Nrf-2/HO-1& TGF-β/Smad pathways.

Article D Peer reviewed Preclinical

Key takeaways

In rats with diabetic kidney disease, combining semaglutide and acarbose prevented glomerular scarring and fibrosis. This combination drug regimen was better than semaglutide alone in this rat model.

Who did this work

Elborei MA · Ashour AA · El-Latif HAEA · Akool ES

Source

Article · PubMed, the drug frontier · 2026 Aug 11
https://pubmed.ncbi.nlm.nih.gov/42580144/