← brief for 2026-08-13 · Slowing decline

Renal glycosuria triggers a coordinated mannose and glutamine metabolic program to maintain glucose homeostasis.

Key takeaways

In mice with glycosuria (sugar in urine), metabolic changes in the liver and kidney limit SGLT2 inhibitor efficacy. These findings suggest a potential target for slowing kidney decline.

Who did this work

Rashid N · Otunla M · Hasan N · Hodges MJ · Qaissi HH · Faniyan TS · Clement PR · Lin P · Kaddah MMY · Cassel TA · Morgan DA · Rahmouni K

Source

Article · PubMed, the drug frontier · 2026 Aug 12
https://pubmed.ncbi.nlm.nih.gov/42593967/