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NUPR1 inhibition prevents mitotic catastrophe: a novel therapeutic strategy for podocyte injury in diabetic kidney disease

Key takeaways

This study used mouse models to show how a drug prevents podocyte injury. Podocytes are kidney cells that filter blood. Results in mice may not translate to humans.

Who did this work

Yating Cai (Guangdong Academy of Medical Sciences) · Li Zhang (Guangdong Academy of Medical Sciences) · Luan Li (Guangdong Academy of Medical Sciences) · 王伟腾 (Guangdong Academy of Medical Sciences) · Yuanhan Chen (Guangdong Academy of Medical Sciences) · Xingchen Zhao (Guangdong Academy of Medical Sciences) · Jiaying Li (Guangdong Academy of Medical Sciences) · Jia Wen (Guangdong Academy of Medical Sciences) · Dantong Li (Guangdong Academy of Medical Sciences) · Manlu Xiao (Guangdong Academy of Medical Sciences) · Ruizhao Li (Ganzhou People's Hospital) · Xinling Liang (Guangdong Academy of Medical Sciences)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-08-12
https://doi.org/10.1038/s41419-026-09152-8