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Low-Protein Diet Supplemented with Ketoanalogues and Progression of Chronic Kidney Disease in Diabetic Patients: A Multicenter Randomized Controlled Trial

Key takeaways

A multi-center trial of 150 patients over 3 years found that a low-protein diet with ketoanalogues slowed kidney disease progression. This was better than standard protein diets, but the effect on mortality was not significantly different between groups. This could help delay dialysis in some patients.

Who did this work

Ramón Paniagua (Mexican Social Security Institute) · Marcela Ávila (Mexican Social Security Institute) · Julia Nava (Fresenius Kabi (Czechia)) · Renata Romero-Salas (Mexican Social Security Institute) · Juan Carlos H Hernández-Rivera (Mexican Social Security Institute) · Oliva Mejía-Rodríguez (Hospital General De Zona) · Giorgina B Picolli (Centre Hospitalier du Mans) · Mexican Nephrology Collaborative Study Group

Source

Paper · OpenAlex, CKD works · 2026-08-12
https://doi.org/10.3390/nu18162630