← brief for 2026-08-13 · Regeneration & devices

Dual inhibition of SGLT 1 and 2 by sotagliflozin alleviates intracellular sodium overload and improves cardiometabolic remodelling in uraemic cardiomyopathy.

Article B Peer reviewed Small trial

Key takeaways

This rat study found that dual SGLT1/2 inhibition prevents sodium overload and heart damage in CKD. The effect was seen over 8 weeks of treatment.

Who did this work

Young M · Karlstaedt A · Dambure S · Miller JJJJ · Guo T · Zhou X · Ramchunder Z · Gonzalez Marques Junior J · Nobles M · Tinker A · Kim K · Purcell AR

Source

Article · PubMed, CKD severity and reversal · 2026 Aug 11
https://pubmed.ncbi.nlm.nih.gov/42578286/