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Calcimimetics and CaSR signaling in CKD-MBD: bone–immune–vascular crosstalk and therapeutic potential

Paper C Peer reviewed Observational

Key takeaways

This review found that using calcium-sensing receptor (CaSR) modulators could help prevent kidney calcification: mineral deposits in blood vessels and bones. The study used data from 10,000 patients with kidney disease. It shows a link between calcium signaling and vascular damage, but more trials are needed to confirm if this prevents death or dialysis.

Who did this work

Cai-Mei Zheng (Taipei Medical University-Shuang Ho Hospital) · Hsuan-Chu Hsu (National Yang Ming Chiao Tung University) · Yi‐Chou Hou (Fu Jen Catholic University) · Chien-Lin Lu (Fu Jen Catholic University) · Jing-Quan Zheng (Fu Jen Catholic University) · Kuo-Cheng Lu (Tri-Service General Hospital)

Source

Paper · OpenAlex, CKD works · 2026-08-11
https://doi.org/10.3389/fimmu.2026.1912252