Decline is not inevitable.
A daily, evidence-graded view of everything moving in kidney research : the drugs that slow decline, the science of regeneration, and the mind-body work.
Air pollution and stress may speed up kidney decline.
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A UK study suggests that high levels of stress markers in the blood are linked to a faster drop in kidney function.
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A large genetic study confirmed that SGLT2 inhibitors protect the heart and kidneys.
Today's news focuses on how outside factors like air quality and stress affect kidney health. Several studies show links between these factors and faster kidney decline. The evidence is observational, so it shows connections rather than proof of cause. These findings highlight the importance of managing overall health and environment.
Disease-Targeted Therapies and eGFR Slope over 2 Years in IgA Nephropathy: A Systematic Review and Network Meta-Analysis
This review compared several new drugs for IgA nephropathy, a common cause of kidney disease. It found that all the drugs slowed the drop in kidney filtering rate over two years. The drugs helped by different amounts, with some working better than others. This is a high-level review of large trials, so it is strong evidence for people with this specific condition.
Semaglutide As a Multiorgan Therapeutic Agent: Evidence for Cardiovascular, Renal, and Hepatic Benefits
This review summarizes large trials of semaglutide, a diabetes drug. It shows the drug slows kidney decline and protects the heart. It also helps with liver health. The evidence comes from big studies with many people.
Air pollution exposure and death from different subtypes of kidney diseases: A nationwide, individual-level, case-crossover study in China.
This large study in China looked at all kidney disease deaths from 2013 to 2019. It found a link between short-term air pollution and dying from kidney disease. This is an observational study, so it shows a connection but not proof of cause. It helps explain why clean air matters for kidney health.
Chronic kidney disease and blood-based biomarkers of Alzheimer's disease: the brain in kidney disease study.
This study checked blood samples from 443 people with kidney disease. It found that lower kidney function was linked to higher levels of a brain protein. This is an observational study, so it shows a link, not proof of cause. It suggests kidney health may affect brain health markers.
Propensity score matched analysis of 5-year outcomes of transcarotid revascularization, transfemoral carotid artery stenting, and carotid endarterectomy
This study compared three types of surgery to clear blockages in the neck arteries. It looked at death rates and stroke risks over five years. This is an observational study, so it shows links but not proof of cause. While not a kidney study, healthy blood flow in the neck is important for overall health, including the kidneys.
Association of non-methane volatile organic compound emission burden with chronic kidney disease: integrated epidemiological, transcriptomic and in vitro analyses
This study linked air pollution to kidney disease in 3,472 people. It shows a link, not proof of cause. It also used lab tests to guess how it works.
Chronic disease burden and health-related quality of life among missouri adults.
This survey of 547 adults found a link between having multiple chronic diseases and lower quality of life. Kidney disease was one of the conditions studied. This shows a link, not proof of cause.
Twenty-four-hour proteinuria and acute kidney injury in women with preeclampsia in Peru
This study looked at 127 women with a pregnancy condition called preeclampsia. It checked if high protein in the urine linked to sudden kidney injury. It shows a link, but not proof of cause.
Renin-angiotensin system inhibitors and arterial stiffness in chronic kidney disease: results from the chronic renal insufficiency cohort.
This study tracked people with kidney disease to see if common blood pressure drugs kept their arteries flexible. It shows a link between the drugs and artery stiffness, but not proof of cause.
Acute Renal and Hemodynamic Risk in Young Adults With Sickle-Cell Trait and Disease: A Propensity-Score-Matched Analysis.
This study compared young adults with sickle-cell disease to those without it. It looked at sudden kidney and blood flow problems. It shows a link to higher risk, but not proof of cause.
Allopurinol underdosage in Danish primary care: a 2-year cohort study of patients with gout, including those with chronic kidney disease
This study looked at people in Denmark who have gout and kidney disease. It found that many of them were not taking the full dose of allopurinol, a drug that lowers uric acid. The study shows a link between low doses and kidney issues, but it does not prove that the low dose caused the problems. This is important because the right dose helps prevent severe joint damage.
Faktor yang Memengaruhi Kualitas Tidur Pasien Gagal Ginjal Kronik
This study asked 83 dialysis patients about their sleep. It found that itching and anxiety hurt sleep quality. It shows a link, but not proof of cause.
Pre-existing heart failure subtype and in-hospital mortality in liver transplantation: a nationwide analysis
This study looked at records of people who had liver transplants. It checked if having heart failure changed the chance of dying in the hospital. It also looked at kidney injury. This is an observational study, so it shows a link, not proof of cause.
Combined assessment of serum netrin-1 and GDF-15 across albuminuria stages in type 2 diabetes
This study looked at blood markers in 60 people with type 2 diabetes. It checked if these markers could spot early kidney damage. The study shows a link between these markers and kidney health. It is an observational study, so it does not prove cause and effect.
Pre-transplant cardiovascular risks and adverse outcomes in patients after receiving kidney transplantation
This study followed 3,562 people who got a kidney transplant. It looked at heart risks before the surgery. The follow-up lasted about 7.7 years on average. It shows a link between heart risks and bad outcomes, but it is not proof of cause.
Canagliflozin ameliorates ferroptosis in diabetic podocytes by PCBP1-enriched extracellular vesicles derived from proximal tubular epithelial cells.
This research shows how the drug canagliflozin protects kidney cells. It works by sending signals from nearby cells to stop a type of cell death. The study used cells and small samples from 60 patients. It was not a test in people, so it does not prove the drug works in the body yet.
Bone marrow mesenchymal stem cells-derived exosomes ameliorate doxorubicin-induced nephrotoxicity via the modulation of pyroptosis-associated signaling.
This study in rats found that stem cell particles can protect kidneys from damage caused by a cancer drug. It showed that the particles reduced kidney injury in the animals. This was in rats, not people yet.
Ferroptosis in podocyte injury in diabetic kidney disease: mechanisms and therapeutic perspectives
This review explains how a type of cell death called ferroptosis harms kidney cells in diabetes. It discusses how high sugar and fats trigger this process. This is a review of lab and animal studies, not people yet.
Integrative network toxicology and single-nucleus transcriptomics reveal molecular overlap between predicted 6PPD-quinone targets and diabetic kidney disease
This study used computer models to look at a chemical from tires. It checked if this chemical might affect kidney cells. The work was done in data sets and models, not in people. It suggests a possible link that needs more testing.
Finerenone Demonstrates Superior Renoprotective and Anti-Fibrotic Efficacy over Eplerenone in Diabetic Nephropathy Rats
This test was done in rats, not people. It compared two drugs to see which one better protected the kidneys from scarring. The new drug, finerenone, worked better than the older one in these animals.