Decline is not inevitable.
A daily, evidence-graded view of everything moving in kidney research : the drugs that slow decline, the science of regeneration, and the mind-body work.
New drugs help slow kidney decline, but no single winner emerged.
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Most other findings today are preliminary or observational, so they show links rather than proven causes.
The main news today is a review of treatments for a specific type of kidney disease. It confirms that new options help slow the loss of kidney function. However, the study did not identify one drug as the best choice. The rest of the day's items were smaller studies or early reports with limited impact.
Disease-Targeted Therapies and eGFR Slope over 2 Years in IgA Nephropathy: A Systematic Review and Network Meta-Analysis
This review compared several new drugs for IgA nephropathy, a common cause of kidney failure. It analyzed large trials to see how well each drug slowed the drop in kidney filtering rate over two years. All the drugs tested helped slow decline, but the study did not find one clear winner. This is a preprint, so it has not yet passed full peer review.
Shared genetic architecture across fibrotic diseases
This large study found that scarring in different organs shares the same genetic roots. It looked at data from many large groups of people. It shows a link, not proof of cause.
GLP-1 Receptor Agonists and Cardiorenal Outcomes in Non-Obese, Non- Diabetic MASLD: A Propensity Score-Matched Study
This preprint studied people with liver disease who were not obese or diabetic. It looked at whether using GLP-1 drugs affected their heart and kidney health. It is an observational study, so it shows a link but not proof of cause. The results are not yet peer reviewed.
Association of Blood Glucose and Lipid Parameters with Increasing Albuminuria Severity in Patients with Type 2 Diabetes Mellitus
This study looked at 180 people with type 2 diabetes. It found a link between high blood sugar or cholesterol and more protein in the urine. This shows a connection, not proof of cause.
Clinical Profile and Predisposing Conditions of Culture-Confirmed Bacteriuria Among Adult Medical Inpatients with Pyuria: A Cross-Sectional Study in Bangladesh
This study described 100 hospitalized adults in Bangladesh who had bacteria in their urine. It looked at their symptoms and health conditions. It is an observational study, so it shows patterns but not proof of cause. It helps doctors understand who is at risk for these infections.
Study of Haematological Profile and Its Alterations in Patients with Chronic Kidney Disease Stages III–V on Conservative Management
This study looked at blood tests for people with advanced kidney disease. It found that blood abnormalities are common in these patients. This shows a link, not proof of cause.
Association between pro- and anti-inflammatory cytokines (IL-6, IL-10), hypothyroidism, and glomerular filtration rate in chronic kidney disease
This study looked at 100 men with kidney disease or low thyroid function. It found links between inflammation markers and kidney function. This shows a connection, not proof of cause.
Dysregulation of adipokines and inflammatory biomarkers in patients with metabolic syndrome and chronic kidney disease: A case-control study
Researchers compared 60 people with both metabolic syndrome and kidney disease to 60 healthy people. They found differences in blood markers for inflammation. This shows a link, not proof of cause.
Association of Anemia with Clinical, Laboratory, and Echocardiographic Characteristics in Patients with Heart Failure with Preserved Ejection Fraction: A Cross-Sectional Study
This study looked at 96 people with a type of heart failure. It found a link between low blood counts and heart health. This shows a connection, not proof of cause.
Dapagliflozin attenuates progression from prefrailty to frailty in patients with hypertension and chronic kidney disease
Older adults with kidney disease and high blood pressure who took a diabetes drug called dapagliflozin had less physical decline over one year. The study followed 135 people. It shows a link, not proof of cause.
Effect of combined sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide-1 receptor agonist therapy in patients with chronic kidney disease: a real-world analysis.
This study looked at real-world data for people with kidney disease. It compared using two types of diabetes drugs together versus using one alone. It tracked kidney and heart outcomes over two years. This is an observational study, so it shows a link, not proof of cause.
Hubungan Self Care Management dan Dukungan Keluarga Dengan Kualitas Hidup Pasien Chronic Kidney Disease (CKD) di Ruang Hemodialisis RSUD dr. Doris Sylvanus Palangka Raya
This study looked at how self-care and family support affect the quality of life for people on dialysis in Indonesia. It shows a link, not proof of cause.
End-Stage Kidney Disease of Unknown Etiology in Southern Iraq: Clinical Characteristics and a Distinct Cardiometabolic Profile Among Patients Receiving Maintenance Hemodialysis
In southern Iraq, many people have kidney failure with no clear cause. This study looked at 394 people on dialysis. It shows a link between this unknown cause and heart and metabolic issues, not proof of cause.
cRGD engineered MSC-derived small extracellular vesicles as targeted delivery vehicles of miR-373 for liver fibrosis therapy
This study tested a new way to treat liver scarring using tiny bubbles from stem cells. It was in cells, not people yet.
Metabolic reprogramming modulates cardiomyocyte hypertrophy via GLS1 in chronic kidney disease in male mice
This study looked at how kidney disease affects the heart in male mice. It found that kidney disease changes how heart cells use energy. This shift may cause the heart muscle to thicken. The work was done in animals, not people yet.
Lactitol Reduces Renal Dysfunction and a Senescence Marker in Aged Mice with Adenine-Induced CKD.
This study was done in mice, not people. It tested a food compound called lactitol in older mice with kidney disease. The mice that took lactitol had less kidney scarring and better function. This shows a possible benefit, but it has not been tested in humans yet.
Albuminuria and Elevated Liver Stiffness in US Adults With Diabetes: A Nationally Representative Cross-Sectional Study
This study looks at the link between protein in the urine and liver stiffness in US adults with diabetes. There is no abstract available, so no specific results are reported yet.
Annual change in estimated glomerular filtration rate and predictors of rapid kidney function decline among antiretroviral therapy-experienced older people with HIV in Uganda, sub-Saharan Africa: A cohort study
This is a preprint of a study that has not yet passed peer review. It tracks kidney function in 500 older people with HIV in Uganda. There are no final results yet.
Association of cardiovascular-kidney-metabolic multimorbidity with clinical outcomes and guideline-directed medical therapy response in patients with heart failure: a multicentre prospective study
This large study followed 7,339 people with heart failure across 32 hospitals in China. It looks at how having kidney disease and diabetes together affects health outcomes. It is a preprint, so it has not passed full peer review yet.
Kidney Transplant Outcomes in Recipients With Congenital Anomalies of the Kidney and Urinary Tract: A Single-Center Propensity Score-Matched Study
This is a preprint of a study that has not yet passed peer review. It compares kidney transplant results for people with birth defects in their urinary tract. There are no final results yet.