Decline is not inevitable.
A daily, evidence-graded view of everything moving in kidney research : the drugs that slow decline, the science of regeneration, and the mind-body work.
A new check helps confirm if you are taking your kidney-protecting medicine.
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A large study found that checking for sugar in urine can help doctors see if patients are actually taking their SGLT2 drugs.
The main news today is a practical tool for monitoring SGLT2 medication use. This helps ensure patients get the full benefit of their treatment. Other items are preliminary and do not change current care.
Hepatitis E virus immunoglobulin G seropositivity and kidney dysfunction among United States adults
This preprint checked if past exposure to Hepatitis E virus is linked to kidney problems in US adults. It used data from national health surveys. It is an observational study, so it shows a link, not proof of cause. The study is not yet peer-reviewed, so the findings are preliminary.
Association between blood urea nitrogen-to-albumin ratio and kidney stones: A cross-sectional study based on NHANES
This preprint looked at a blood test ratio called BAR and its link to kidney stones. It used data from the NHANES survey. It is an observational study, so it shows a link, not proof of cause. The study is not yet peer-reviewed, so the findings are preliminary.
CONTRAST-INDUCED NEPHROPATHY IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE AND PROGNOSIS OF CHRONIC KIDNEY DISEASE
This study looked at 462 people with heart disease who had a dye test. It checked if the dye caused kidney damage. It also tracked what happened to them over one year. This is an observational study, so it shows a link but not proof of cause. It helps us understand the risks of these tests.
Efficacy and safety of telitacicept combined with standard of care in patients with proliferative lupus nephritis: a real-world retrospective study.
This study looked at 112 people with lupus kidney disease. It compared a drug called telitacicept with standard care. It is a retrospective study, so it shows a link, not proof of cause. The drug may help control the disease.
Clinical manifestations, treatment and prognosis analysis of childhood ANCA-associated vasculitis.
This study reviewed children with a rare blood vessel inflammation. It looked at how the disease affects their kidneys. It is an observational study, so it shows links but not proof of cause. It helps doctors understand this rare condition better.
Chronic Kidney Disease Severity and Progression to Proliferative Diabetic Retinopathy.
This study looked at people with type 2 diabetes and eye disease. It found a link between kidney disease and worse eye problems. The study is observational, so it shows a connection but not proof of cause. It does not test a new treatment.
Association between central thyroid hormone dysregulation and chronic kidney disease in type 2 diabetes: a cross-sectional study.
This study looked at 2,759 people with type 2 diabetes. It found a link between thyroid hormone issues and kidney disease. This shows a connection, but it does not prove that one causes the other.
African-specific variants at the GATM locus and genetic bias in creatinine-based GFR estimation
This study explains why kidney function tests can be less accurate for people of African ancestry. A specific gene change causes the body to make more creatinine, a waste product. This raises the creatinine level in the blood without actually changing how well the kidneys filter. The result is that standard tests may underestimate kidney function in these patients. This finding helps doctors interpret test results more fairly.
Perinatal Risk and Outcomes Among Individuals Insured by Medicare
This study compared pregnant women on Medicare with those on other insurance. It looked at health risks and baby outcomes. This is an observational study, so it shows a link but not proof of cause. It helps us understand the challenges for pregnant people with chronic conditions.
Increased mechanical load remodels the glomerular matrix and accelerates Alport kidney disease: processed data and analysis code
This study used mice to see how extra stress on the kidney changes its structure. It found that this stress can speed up a specific type of kidney disease in the animals. The data is from lab tests, not from people yet.
Cadherin-11 and the mechanobiology of the fibrogenic niche
Researchers found that blocking a protein called cadherin-11 can limit scarring in the kidneys. This was tested in animal models of kidney injury, not in people yet. The protein helps cells generate force, which drives the scarring process. Stopping this process preserved kidney function in the animals. This suggests a new target for future drugs to prevent kidney damage.
A Woman With Generalized Abdominal Pain
This is a case report about an 81-year-old woman with stage 3 kidney disease. She went to the emergency room with belly pain. Doctors used ultrasound to find air in her belly. This report describes one person's experience. It does not test a new treatment or show what works for many people.
Poor prognosis of acute kidney injury superimposed on chronic kidney disease: potential mechanisms, risk factors and novel biomarkers
This review is starting. It discusses why sudden kidney injury is dangerous for people with long-term kidney disease. There are no results yet.
Integrative multi-omics analysis prioritizes compartment-specific candidate targets of gut microbiota metabolites in diabetic kidney disease
This study is starting. It looks for gut bacteria targets that might help people with diabetic kidney disease. There are no results yet.
Tonsillar Tfh cells contribute to the pathogenesis of IgA nephropathy in collaboration with memory B cells
This study is starting. It looks at how immune cells in the tonsils may cause a type of kidney disease. There are no results yet.
Endocrine regulation of uromodulin in aging
This review is starting. It discusses how hormones control a kidney protein as people age. There are no results yet.
Identification of a novel metabolic and lipidomic signature for 90-day functional outcome after ischemic stroke: an exploratory proof-of-concept study
This study is starting. It looks for blood markers that predict recovery after a stroke. There are no results yet.
Vitamin D deficiency and the long-term risk of new-onset abdominal aortic aneurysm and severe aortic events: a multicenter propensity score–matched cohort study
This study is starting. It looks at the link between low vitamin D and a bulge in the main artery of the belly. There are no results yet.
Development and validation of an explainable machine learning model for differentiating diabetic nephropathy from diabetic retinopathy in patients with type 2 diabetes
This study is starting. It aims to build a computer model that tells the difference between kidney and eye damage in people with type 2 diabetes. There are no results yet.
New Insights into the Role of Mitochondrial Dysfunction in Diabetic Kidney Disease in the Omics Era.
This is a review of how energy problems in cells drive diabetic kidney disease. It explains the science behind the damage. There are no new trial results in this article. It summarizes what is already known.