Decline is not inevitable.
A daily, evidence-graded view of everything moving in kidney research : the drugs that slow decline, the science of regeneration, and the mind-body work.
Stress and diabetes may speed up kidney damage and lower fitness.
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High stress markers in the blood are linked to a faster drop in kidney function.
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Kidney patients with diabetes have much lower heart and lung fitness than those without diabetes.
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A new anemia drug works as well as standard shots for people on dialysis.
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Home-based exercise improved muscle health in a small trial of people with kidney disease.
Today's news focuses on how stress and diabetes affect the body. High stress levels and diabetes are linked to faster kidney decline and lower fitness. A new anemia drug showed promise for dialysis patients. One study on cancer drugs in rats is still early and not yet proven for humans.
Semaglutide As a Multiorgan Therapeutic Agent: Evidence for Cardiovascular, Renal, and Hepatic Benefits
This review summarizes large trials of semaglutide, a diabetes drug. It shows the drug slows kidney decline and protects the heart. It also helps with liver health. The evidence comes from big studies with many people.
Allopurinol underdosage in Danish primary care: a 2-year cohort study of patients with gout, including those with chronic kidney disease
This study looked at people in Denmark who have gout and kidney disease. It found that many of them were not taking the full dose of allopurinol, a drug that lowers uric acid. The study shows a link between low doses and kidney issues, but it does not prove that the low dose caused the problems. This is important because the right dose helps prevent severe joint damage.
Acute Renal and Hemodynamic Risk in Young Adults With Sickle-Cell Trait and Disease: A Propensity-Score-Matched Analysis.
This study compared young adults with sickle-cell disease to those without it. It looked at sudden kidney and blood flow problems. It shows a link to higher risk, but not proof of cause.
Renin-angiotensin system inhibitors and arterial stiffness in chronic kidney disease: results from the chronic renal insufficiency cohort.
This study tracked people with kidney disease to see if common blood pressure drugs kept their arteries flexible. It shows a link between the drugs and artery stiffness, but not proof of cause.
Twenty-four-hour proteinuria and acute kidney injury in women with preeclampsia in Peru
This study looked at 127 women with a pregnancy condition called preeclampsia. It checked if high protein in the urine linked to sudden kidney injury. It shows a link, but not proof of cause.
Faktor yang Memengaruhi Kualitas Tidur Pasien Gagal Ginjal Kronik
This study asked 83 dialysis patients about their sleep. It found that itching and anxiety hurt sleep quality. It shows a link, but not proof of cause.
Pre-existing heart failure subtype and in-hospital mortality in liver transplantation: a nationwide analysis
This study looked at records of people who had liver transplants. It checked if having heart failure changed the chance of dying in the hospital. It also looked at kidney injury. This is an observational study, so it shows a link, not proof of cause.
Combined assessment of serum netrin-1 and GDF-15 across albuminuria stages in type 2 diabetes
This study looked at blood markers in 60 people with type 2 diabetes. It checked if these markers could spot early kidney damage. The study shows a link between these markers and kidney health. It is an observational study, so it does not prove cause and effect.
Pre-transplant cardiovascular risks and adverse outcomes in patients after receiving kidney transplantation
This study followed 3,562 people who got a kidney transplant. It looked at heart risks before the surgery. The follow-up lasted about 7.7 years on average. It shows a link between heart risks and bad outcomes, but it is not proof of cause.
Bone marrow mesenchymal stem cells-derived exosomes ameliorate doxorubicin-induced nephrotoxicity via the modulation of pyroptosis-associated signaling.
This study in rats found that stem cell particles can protect kidneys from damage caused by a cancer drug. It showed that the particles reduced kidney injury in the animals. This was in rats, not people yet.
Ferroptosis in podocyte injury in diabetic kidney disease: mechanisms and therapeutic perspectives
This review explains how a type of cell death called ferroptosis harms kidney cells in diabetes. It discusses how high sugar and fats trigger this process. This is a review of lab and animal studies, not people yet.
Integrative network toxicology and single-nucleus transcriptomics reveal molecular overlap between predicted 6PPD-quinone targets and diabetic kidney disease
This study used computer models to look at a chemical from tires. It checked if this chemical might affect kidney cells. The work was done in data sets and models, not in people. It suggests a possible link that needs more testing.
Finerenone Demonstrates Superior Renoprotective and Anti-Fibrotic Efficacy over Eplerenone in Diabetic Nephropathy Rats
This test was done in rats, not people. It compared two drugs to see which one better protected the kidneys from scarring. The new drug, finerenone, worked better than the older one in these animals.
Combined Versus Multicomponent Training in People With Chronic Kidney Disease Stages 3a and 3b
This trial is starting to test different exercise programs for people with kidney disease. It will compare combined and multicomponent training. There are no results yet.
Prognostic nutritional indices and longitudinal kidney outcomes and mortality in adults with type 2 diabetes: a systematic review
This is a registration for a review of how nutrition scores link to kidney outcomes. It is a planned study. There are no results yet.
Biopsy-Proven Renal AA Amyloidosis Revealing Underlying Pulmonary Tuberculosis With the Kidney as an Innocent Bystander: A Case Report and Literature Review
This is a report on one patient whose kidney disease came from an old lung infection. It is a single case, so it does not show a general rule. There are no broad results yet.
Childhood Food Insecurity and the Development of Atherosclerotic Cardiovascular Disease: Dietary, Metabolic, and Psychosocial Pathways
This paper discusses how not having enough food in childhood affects heart health later. It is a review of existing knowledge. There are no new results from this specific paper.
TCT-626 Comparative Effectiveness of Contemporary Pharmacologic Therapies and Renal Denervation for Resistant Hypertension: A Systematic Review and Network Meta-analysis
This is a review of studies comparing a nerve procedure to new blood pressure drugs. It looks at people whose blood pressure is hard to control. There are no results yet from this specific paper.
Brain activity characteristics of chronic kidney disease-associated pruritus in maintenance hemodialysis patients: a resting-state fMRI study
This study used brain scans to look at itching in people on dialysis. It is a new paper, so there are no results yet to report.
Interstitial lung disease unmasked as myeloperoxidase-antineutrophil cytoplasmic antibody-associated vasculitis following acute kidney injury
This is a case report about one woman who had lung and kidney problems. It describes how her condition was finally diagnosed. It is a single person's story, not a large study. There are no results yet.