Decline is not inevitable.
A daily, evidence-graded view of everything moving in kidney research : the drugs that slow decline, the science of regeneration, and the mind-body work.
New data suggests diabetes drugs may help protect physical strength in older adults.
Today's news focuses on how diabetes medications might help protect the body beyond just controlling blood sugar. One study looked at physical strength in older adults, while another explored the shared genes behind organ scarring. Most of the other reports were small studies looking at links between kidney disease and other health issues.
Shared genetic architecture across fibrotic diseases
This large study found that scarring in different organs shares the same genetic roots. It looked at data from many large groups of people. It shows a link, not proof of cause.
Effect of combined sodium-glucose cotransporter 2 inhibitors and glucagon-like peptide-1 receptor agonist therapy in patients with chronic kidney disease: a real-world analysis.
This study looked at real-world data for people with kidney disease. It compared using two types of diabetes drugs together versus using one alone. It tracked kidney and heart outcomes over two years. This is an observational study, so it shows a link, not proof of cause.
Dapagliflozin attenuates progression from prefrailty to frailty in patients with hypertension and chronic kidney disease
Older adults with kidney disease and high blood pressure who took a diabetes drug called dapagliflozin had less physical decline over one year. The study followed 135 people. It shows a link, not proof of cause.
Association of Anemia with Clinical, Laboratory, and Echocardiographic Characteristics in Patients with Heart Failure with Preserved Ejection Fraction: A Cross-Sectional Study
This study looked at 96 people with a type of heart failure. It found a link between low blood counts and heart health. This shows a connection, not proof of cause.
Dysregulation of adipokines and inflammatory biomarkers in patients with metabolic syndrome and chronic kidney disease: A case-control study
Researchers compared 60 people with both metabolic syndrome and kidney disease to 60 healthy people. They found differences in blood markers for inflammation. This shows a link, not proof of cause.
Association between pro- and anti-inflammatory cytokines (IL-6, IL-10), hypothyroidism, and glomerular filtration rate in chronic kidney disease
This study looked at 100 men with kidney disease or low thyroid function. It found links between inflammation markers and kidney function. This shows a connection, not proof of cause.
Study of Haematological Profile and Its Alterations in Patients with Chronic Kidney Disease Stages III–V on Conservative Management
This study looked at blood tests for people with advanced kidney disease. It found that blood abnormalities are common in these patients. This shows a link, not proof of cause.
End-Stage Kidney Disease of Unknown Etiology in Southern Iraq: Clinical Characteristics and a Distinct Cardiometabolic Profile Among Patients Receiving Maintenance Hemodialysis
In southern Iraq, many people have kidney failure with no clear cause. This study looked at 394 people on dialysis. It shows a link between this unknown cause and heart and metabolic issues, not proof of cause.
Hubungan Self Care Management dan Dukungan Keluarga Dengan Kualitas Hidup Pasien Chronic Kidney Disease (CKD) di Ruang Hemodialisis RSUD dr. Doris Sylvanus Palangka Raya
This study looked at how self-care and family support affect the quality of life for people on dialysis in Indonesia. It shows a link, not proof of cause.
Lactitol Reduces Renal Dysfunction and a Senescence Marker in Aged Mice with Adenine-Induced CKD.
This study was done in mice, not people. It tested a food compound called lactitol in older mice with kidney disease. The mice that took lactitol had less kidney scarring and better function. This shows a possible benefit, but it has not been tested in humans yet.
Metabolic reprogramming modulates cardiomyocyte hypertrophy via GLS1 in chronic kidney disease in male mice
This study looked at how kidney disease affects the heart in male mice. It found that kidney disease changes how heart cells use energy. This shift may cause the heart muscle to thicken. The work was done in animals, not people yet.
cRGD engineered MSC-derived small extracellular vesicles as targeted delivery vehicles of miR-373 for liver fibrosis therapy
This study tested a new way to treat liver scarring using tiny bubbles from stem cells. It was in cells, not people yet.
Kidney Endpoints in ANCA-Associated Vasculitis – Position Report from the European Vasculitis Society Focus Group Meetings
This report discusses how doctors measure kidney health in a specific type of blood vessel disease. It aims to create standard ways to track kidney outcomes. There are no new patient results in this document. It is a position report from a medical society.
Evaluate the Efficacy and Safety of ABP-671 in Subjects With Chronic Kidney Disease and Hyperuricaemia
This is a new trial that is starting. It will test a drug called ABP-671 in people with kidney disease and high uric acid. The study is planned to last 40 weeks. There are no results yet because the trial is just beginning.
Cardiovascular-kidney-metabolic syndrome: conceptual framework, clinical implications, and therapeutic perspectives with a focus on SGLT2 inhibitors.
This review explains how heart, kidney, and metabolic health are connected. It focuses on a class of drugs called SGLT2 inhibitors. It discusses how these drugs may help manage this combined condition. It is a review of existing knowledge, not a new trial.
When red eyes signal glomerular disease: IgA nephropathy presenting as recurrent episcleritis and scleritis.
This report describes three patients who had eye inflammation before their kidney disease was found. The eye issues were a sign of a specific kidney condition called IgA nephropathy. It is a case report, not a large study with general results.
Nonsurgical Management of Postpartum Arterial Mesenteric Thrombosis: An Exceptional Outcome
This report describes one woman with kidney disease who had a blood clot in her gut after giving birth. She was treated with medicine instead of surgery. This is a single case, so it does not prove what works for everyone.
Integrated Patient Care Intradialysis Programme in Hemodialysis Through a Virtual Health Platform
This trial is starting to test a virtual health program for people on dialysis. It will offer exercise, nutrition, and mental health support. The goal is to improve overall well-being during treatment. There are no results yet.