Decline is not inevitable.
A daily, evidence-graded view of everything moving in kidney research : the drugs that slow decline, the science of regeneration, and the mind-body work.
New data shows diabetes drugs protect kidneys and stress may speed decline.
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Large studies confirm that SGLT2 inhibitors and GLP1 agonists protect both the heart and kidneys in similar ways.
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High levels of stress markers in the blood are linked to a faster drop in kidney function.
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A new anemia drug works as well as standard shots for people on dialysis.
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A small trial suggests home-based exercise can improve muscle health for people with kidney disease.
Today's news focuses heavily on the benefits of diabetes medications for kidney protection. Researchers also found that high stress levels may accelerate kidney decline. While some findings are from smaller studies, the large data sets support the use of specific drugs to protect heart and kidney health.
Associations of renal complement deposition with oxford MEST-C pathological lesions and renal outcomes in Iga nephropathy: a meta-analysis
This review combined data from many studies on IgA nephropathy. It looked at immune markers found in kidney tissue. The goal was to see if these markers predict how fast the disease gets worse. This is a strong type of evidence because it pools many studies together.
Safety and Tolerability of Sodium-Glucose Cotransporter-2 Inhibitors: A State-of-the-Art Narrative Review.
This review looked at how safe SGLT-2 drugs are for people with kidney disease. It found that these drugs are generally well tolerated. They help protect the kidneys and the heart. This is strong evidence for their use in daily care.
Machine Learning for Early Detection and Progression Prediction of Global Chronic Kidney Disease: A Systematic Review of Externally Validated Models
This review looked at 16 studies that used AI to predict kidney disease. Most AI tools are only tested on the data used to build them. This review checked if they work on new patient groups. It found that very few of these tools have been properly tested outside their original data.
Canonical correlation analysis identifies single nucleotide polymorphism combinations and gene expression associated with membranous nephropathy
Researchers analyzed genetic data to find markers for membranous nephropathy, a type of kidney disease. They identified specific gene combinations linked to the condition. This is an observational genetic study, so it shows a link, not proof of cause.
Beyond Traditional Risk Factors: The Role of the CYP11B2 C(-344)T Polymorphism in Atherosclerosis and Cardiorenal Syndrome Phenotypes in Diabetes Mellitus
Researchers studied 269 people with diabetes and 50 healthy controls. They found that a specific gene change was more common in people with diabetes. This gene change was also linked to worse heart and kidney health. This study shows a link, not proof of cause.
Association between pancreatic ectopic fat deposition and QCT-assessed bone mass status in patients with chronic kidney disease: a cross-sectional study
This study looked at 327 people with chronic kidney disease. It checked if extra fat in the pancreas is linked to weaker bones. The results show a link, but they do not prove that the fat causes the bone loss. This is an observational study, so it cannot show cause and effect.
Stress hyperglycemia ratio and albuminuria in Shandong and Jiangsu, China: a two-center cross-sectional study with inter-hospital external evaluation
This study looked at 2,378 adults in China. It found a link between a blood sugar measure and protein in the urine. It shows a connection, but it is not proof of cause.
Association Between Endothelial Activation and Stress Index and Microalbuminuria.
This study found a link between a blood test marker and early kidney damage. The marker is called the Endothelial Activation and Stress Index. It shows a connection, but it is not proof that the marker causes the damage.
Early Renal Trajectory in Sepsis-Associated Acute Kidney Injury: Role of Norepinephrine and Fluid Balance
This study followed 209 patients with kidney injury caused by sepsis. It looked at how blood pressure drugs and fluid balance affected kidney function. It shows a link between these factors and kidney outcomes, but it is not proof of cause.
Longitudinal Changes in Renal, Glycemic, Metabolic, Hematological, and Inflammatory Parameters in Patients with Diabetic Kidney Disease Treated with Empagliflozin or Dapagliflozin: A 12-Month Real-World Cohort Study
This study followed 452 people with diabetic kidney disease for 12 months. They took a diabetes drug called empagliflozin or dapagliflozin. The study looked at how their kidney and blood markers changed. It is a preprint, so it has not passed peer review yet.
Oral ferrous fumarate dosing regimens in peritoneal dialysis: a single-center retrospective audit
This study looked at how often people on peritoneal dialysis took their oral iron pills. It found that taking the pills less often may help the body absorb the iron better. This is an observational study, so it shows a link but not proof of cause.
Estimated glomerular filtration rate in extracranial and intracranial atherosclerotic stenosis among patients with ischaemic stroke: a cross-sectional study
This study looked at people who had a stroke. It checked if kidney function linked to the type of artery blockage. It shows a link, but it does not prove that kidney health causes the stroke type.
Association of serum phosphorus and incidence of atrial fibrillation in chronic kidney disease stage 3
This study looked at 21,078 people with stage 3 kidney disease. It checked if high phosphorus levels linked to a heart rhythm problem. It shows a link, but it does not prove that phosphorus causes the heart issue.
High-density lipoprotein cholesterol-related inflammatory markers as indicators of diabetic kidney disease in diabetes with sleep disturbance
This study looked at 763 people with diabetes and sleep issues. It checked if certain blood markers linked to kidney damage. It shows a link, but it does not prove that the markers cause the damage.
Vitamin D Status and Its Correlation with Serum Calcium and Phosphorus in Pediatric Nephrotic Syndrome: A Prospective Observational study
This study checked vitamin D levels in 75 children with a kidney condition called nephrotic syndrome. It found a link between low vitamin D and changes in calcium and phosphorus. This shows a connection, but it does not prove that vitamin D causes the changes.
HUBUNGAN LAMA HEMODIALISIS DENGAN FUNGSI KOGNITIF, STATUS GIZI DAN STRES PADA PASIEN PENYAKIT GINJAL KRONIK DI RSU HAJI MEDAN
This study looked at people with kidney disease who get dialysis. It checked if the time spent on dialysis links to stress, thinking skills, and nutrition. The results show a connection, but they do not prove that dialysis causes these issues. This is an observational study, so it shows a link, not proof of cause.
Performance of a screening strategy for identifying locomotor disorders in older patients during pre-kidney transplantation assessment
This study looked at older people waiting for a kidney transplant. It tested if a simple movement test could spot those who need physical therapy. The results show a link between the test and movement issues, but it is not proof of cause.
Transfusion-free kidney transplantation in Jehovah’s witnesses: a propensity-score matched cohort study
This study followed people who refused blood transfusions for religious reasons. It compared their kidney transplants to others who did get blood. It shows a link between the protocol and outcomes, but it is not a random trial.
Global burden of chronic kidney disease attributable to hypertension due to high body mass index: projections to 2050
This study used global data to project how many people will get kidney disease from high blood pressure caused by high weight. It estimates the health burden up to the year 2050. It shows a link between weight, blood pressure, and kidney disease, but it is a projection, not a treatment trial.
Prevalence and Clinical Characteristics of Renal Disease in Hiv Patients at a Tertiary Care Hospital
This preprint looked at how common kidney disease is in people with HIV. It was a cross-sectional study at one hospital in India. It shows a link between HIV and kidney issues, but it is not proof of cause. This has not yet been peer reviewed.