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Integrative network toxicology and single-nucleus transcriptomics reveal molecular overlap between predicted 6PPD-quinone targets and diabetic kidney disease

Article D Peer reviewed Preclinical

Key takeaways

This study used computer models to look at a chemical from tires. It checked if this chemical might affect kidney cells. The work was done in data sets and models, not in people. It suggests a possible link that needs more testing.

Who did this work

Siyuan Song · Qiling Zhang · Xizi Li · Peipei Zhou · Ying Tan · Xiqiao Zhou · Liji Huang · Jiangyi Yu

Source

Article · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-10-31
https://doi.org/10.1186/s12882-026-05473-0