← brief for 2026-11-01 · Regeneration & devices

Bone marrow mesenchymal stem cells-derived exosomes ameliorate doxorubicin-induced nephrotoxicity via the modulation of pyroptosis-associated signaling.

Article D Peer reviewed Preclinical

Key takeaways

This study in rats found that stem cell particles can protect kidneys from damage caused by a cancer drug. It showed that the particles reduced kidney injury in the animals. This was in rats, not people yet.

Who did this work

Shahin RK (Biochemistry Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, 11829, Cairo, Egypt.) · Elazazy O (Biochemistry Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, 11829, Cairo, Egypt.) · Wahdan SA (Pharmacology and Toxicology Department, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt.) · AbdelHamid SG (Biochemistry and Molecular Biology Department, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt. [email protected].)

Source

Article · Europe PMC, CKD · 2026-10-31
https://doi.org/10.1186/s10020-026-01655-6