← brief for 2026-10-09 · Slowing decline

An inducible co-stimulator ligand (ICOSL)-based peptide therapy for proteinuric kidney diseases targeting αvβ3 integrin

Article D Peer reviewed Preclinical

Key takeaways

Researchers designed a new small peptide drug to stop protein from leaking into the urine. The drug targets a specific protein called an integrin that helps hold the kidney's filter together. This work was done in the lab, not in people yet. It aims to protect the kidney's filtering barrier.

Who did this work

Alexis Paulina Jiménez‐Uribe · Yan Xu · 曹艳霞 · Ryan Spear · Kwi Hye Koh · Adrian Pablo Mansini · Ariana G. Alcantar · Felix Kliewe · Nicole Endlich · Jochen Reiser · Steve Mangos · Eunsil Hahm

Source

Article · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-10-09
https://doi.org/10.1186/s43556-026-00594-2