← brief for 2026-10-08 · Transplant & xeno

Innate allorecognition induces HSP70 in monocytes contributing to renal allograft rejection

Key takeaways

This study looked at how the body rejects kidney transplants. It found that a specific protein, HSP70, plays a role in the immune response. The work was done in mice and cells, not in people yet. It helps explain the biology of rejection, but it is not a new treatment for patients.

Who did this work

Zeping Gui (University of Pittsburgh Medical Center) · Neda Feizi (University of Pittsburgh Medical Center) · Berkay Demirors (University of Pittsburgh Medical Center) · Canxiang Lin (University of Pittsburgh Medical Center) · Hehua Dai (University of Pittsburgh Medical Center) · Mouhamad Al Moussawy (University of Pittsburgh Medical Center) · Andrew Friday (University of Pittsburgh Medical Center) · Steven M. Sanders (University of Pittsburgh Medical Center) · Latha Halesha (University of Pittsburgh Medical Center) · Amanda L. Williams (University of Pittsburgh Medical Center) · Faruk Sacirbegovic (University of Pittsburgh Medical Center) · Parmjeet S. Randhawa (University of Pittsburgh)

Source

Article · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-10-07
https://doi.org/10.1172/jci.insight.197348