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Individualized Treatment Effects of Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized with Acute Infection

Key takeaways

This is a secondary analysis of a large trial called ACORN. It looked at how two different antibiotics affect kidney injury in hospitalized adults. The original trial had hundreds of participants. This analysis checks if certain patient traits change the drug's effect. It helps tailor antibiotic choices to protect kidneys.

Who did this work

Edward T. Qian (Vanderbilt University Medical Center) · Emma J. Graham Linck (University of Wisconsin–Madison) · Alexandra B. Spicer (University of Wisconsin–Madison) · Kevin G Buell (Rush University Medical Center) · Jonathan D Casey (Vanderbilt University Medical Center) · Kevin P. Seitz (Vanderbilt University Medical Center) · Wesley H. Self (Vanderbilt University Medical Center) · Li Wang (Vanderbilt University) · Adam Wright (Vanderbilt University Medical Center) · T Rice (Vanderbilt University Medical Center) · Matthew W Semler (Vanderbilt University Medical Center) · Matthew M. Churpek (University of Wisconsin–Madison)

Source

Article · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-10-07
https://doi.org/10.1093/ajrccm/aamag544