← brief for 2026-10-06 · Slowing decline

TNFSF14 deficiency attenuates the ischemia/reperfusion-induced acute kidney injury-to-chronic kidney disease transition by upregulating PGC-1α expression

Key takeaways

This study used mice to see if a specific gene change could slow kidney damage. It found that reducing one gene helped prevent scarring in the kidneys. This was in animals, not people yet, so it is early research.

Who did this work

Ximing Chen (Army Medical University) · Quan‐you Zheng (Army Medical University) · Jian Hu (Second Affiliated Hospital of Chongqing Medical University) · Yi-heng Liu (Second Affiliated Hospital of Chongqing Medical University) · Long Sheng-jie (Second Affiliated Hospital of Chongqing Medical University) · Guiqing Li (Army Medical University) · Jian Chen (Army Medical University) · Gui-lian Xu (Army Medical University) · K Zhang (Second Affiliated Hospital of Chongqing Medical University)

Source

Article · OpenAlex, CKD works · 2026-10-05
https://doi.org/10.1038/s41598-026-74140-z