Kidney research, 2026-09-26
A new drug shows better results than steroids for a common kidney disease.
-
A new study found that Nefecon works better than steroids for a common kidney condition.
-
Other reports cover a rare case of kidney damage from leukemia and a new AI tool for heart rhythms.
The main news today is a study showing a specific drug performs better than steroids for a common kidney disease. The other items are less relevant to most people with stage 3 CKD. They cover a rare leukemia case and a new heart rhythm tool.
Long-term outcomes of childhood nephrotic syndrome
This review summarizes what happens to children with a kidney condition called nephrotic syndrome. It explains how steroids are used as the first treatment. It also notes that some...
Cardiovascular-Kidney-Metabolic Syndrome and Its Hepatic Dimension: A Narrative Review.
This review looks at how heart, kidney, and liver health are connected. It finds that metabolic issues can harm all three organs. This is a link, not proof of cause. It helps...
Features of Lipid Disorders in Cardiovascular-Kidney-Metabolic Syndrome.
This review explains how bad cholesterol patterns drive kidney damage in metabolic syndrome. It links high fats in the blood to faster kidney decline. There are no new trial...
Metabolic and Lipoprotein Changes in Type 2 Diabetes Patients Treated with Empagliflozin.
A diabetes drug called empagliflozin changed blood markers in 42 people over 1 to 3 months. It raised magnesium and hemoglobin levels. This study shows a link, not proof of cause.
Data-Driven Multidimensional Clinical Phenotypes and Longitudinal Changes in Type 2 Diabetes Mellitus: A Retrospective Cohort Study.
Researchers looked at 807 adults with type 2 diabetes to find groups based on kidney and inflammation markers. They tracked how kidney function changed over six to twelve months....
Effects of SGLT2 Inhibitors in Rodent Models of Diabetic Nephropathy.
This review looks at how diabetes drugs protect kidneys in mice and rats. It covers more than 170 studies in animals. These results are not in people yet.
Circulating ANGPTL4 predicts CKD and ESKD risk: insights from large-scale proteomics and senescence mechanisms
A blood protein called ANGPTL4 was linked to higher risk of kidney failure in 53,014 people. This study shows a link, not proof of cause.
Analysis code for "Association of pretransfusion platelet count with mortality in patients with sepsis-associated acute kidney injury"
This is the computer code for a study on blood counts in sick patients. There are no new results in this file.
Supplemental Material for: The clinical and pathological significance of CD9 in IgA nephropathy with crescent lesions
These are extra files for a study on a kidney disease marker called CD9. There are no new results in this file.
Histopathological landscape of diabetic nephropathy: Insights from native kidney biopsies at a tertiary care centre in South India
Doctors at one kidney hospital in Bangalore, India, looked back at 598 kidney biopsies (small tissue samples) taken during 2023. They found 115 cases of diabetic kidney damage,...
Supplemental Material for: Effect of Hydroxychloroquine on Proteinuria and Inflammatory Markers
This small trial tested hydroxychloroquine, a drug that calms the immune system, in 43 people with long-term inflammation of the kidney filters. They were already on standard...
Clinical manifestations and proportions of severe outcomes in pediatric acute post-streptococcal glomerulonephritis: a systematic review and meta-analysis of predominantly hospital-based cohorts
This review pooled studies of children whose kidneys became inflamed after a strep infection. It counted how often they had high blood pressure, blood in the urine, sudden kidney...
DIABETIC KIDNEY DISEASE: EARLY BIOMARKERS, NOVEL THERAPEUTIC INTERVENTIONS, AND PROGRESSION MITIGATION
This is a general overview of diabetic kidney disease, posted online and not peer reviewed. Its short summary says only that kidney disorders are a big problem worldwide. It...
Early Renal Effects After Radioactive Iodine Therapy in Differentiated Thyroid Cancer: A Prospective Observational Study
This study followed 120 people getting radioactive iodine for thyroid cancer, 40 at each of three dose levels. It measured four urine markers of early kidney injury on day 1 and...
Proteinuria-Aware Gated Survival Learning for Time-Dependent Prediction of Chronic Kidney Disease Progression and Renal Replacement Therapy
This item is a data record for a computer model that predicts kidney disease. It is not a standard journal article. There are no clinical results to report here.
Predictors of renal and patient survival in lupus nephritis: a 28-year single-center cohort study
This study tracked 147 people with lupus kidney disease for about 3 years. It found factors that predict long-term survival. Because it is an observational study, it shows a link,...
A blood test-derived skeletal muscle index combined with handgrip strength identifies a sarcopenia-related high-risk phenotype in non-dialysis-dependent chronic kidney disease
A new blood test tool can flag high-risk muscle loss in 1,403 people with kidney disease. This is an observational study, so it shows a link, not proof of cause. It helps doctors...
Aldosterone Synthase Inhibitors: Emerging Therapeutic Strategies in Resistant Hypertension.
This is a review of new blood pressure drugs for hard-to-control cases. It summarizes existing research but does not report new trial results. It discusses how these drugs might...
Indoxyl Sulfate, Cardiac Biomarkers, and Left Ventricular Wall Thickening in Cats with Chronic Kidney Disease.
This study looked at 31 cats with kidney disease and heart changes. It was in animals, not people yet. It may help us understand how kidney disease affects the heart in general.
The Unfinished Story of Sickle Cell Nephropathy: A Narrative Review of Knowledge Gaps and Research Imperatives.
This review looks at kidney damage caused by sickle cell disease. It notes that standard tests often miss the problem early on. The authors list the gaps in current knowledge and...
Macrophage pyroptosis in lupus nephritis - Novel insights into renal pathogenesis and clinical correlates: A cross-sectional study.
This study looked at kidney tissue from 49 people with lupus nephritis. It found a specific type of cell death linked to the disease. This is an observational study, so it shows a...
Prognostic value of RDW and its derivatives in ICU patients with hypertensive chronic kidney disease.
This study analyzed data from 6,731 patients in the ICU. It looked at blood markers to predict outcomes in people with high blood pressure and kidney disease. This is an...
Autonomic-Immune Crosstalk in Lupus: Impaired Cholinergic Signaling and Consequences for Cardiovascular-Renal Physiology
This study used mice to test a drug called galantamine. The drug helped reduce kidney scarring and improved survival in the animals. This was done in animals, not people yet.
Cardiac remodeling and subclinical myocardial dysfunction in patients with chronic kidney disease undergoing maintenance hemodialysis: a retrospective echocardiographic study
This study looked at heart scans for 120 people on dialysis and 60 healthy controls. It found that people with kidney disease often have heart muscle changes that go beyond just...
Cardiorenal Syndrome: Pathophysiology, Management, and the Challenge of Therapeutic Inertia
This is a review article about how heart and kidney problems affect each other. It cites a 2024 meta-analysis showing that about 49% of people with heart failure also have kidney...
Clinicopathological evaluation of renal disease profile in 100 nephrectomy specimens in tertiary care hospital in Himachal Pradesh
This study looked at 100 kidneys removed from patients over two years. It found that 80% of the cases were non-cancerous, while 20% were cancerous. This is an observational report...
Chronic Kidney Disease Stage and Hospital Mortality in Critically Ill Adults
This article is about how kidney disease stage affects survival in the hospital. It does not have an abstract, so we cannot see the specific results. It is a published paper, but...
POSSIBILITIES FOR PREDICTING THE PROGRESSION OF CHRONIC KIDNEY DISEASE IN PATIENTS WITH ISCHEMIC HEART DISEASE USING BIOMARKER PANELS
This item is a record for a study on predicting kidney disease progression. It was posted on a data repository, not a peer-reviewed journal. There is no abstract or data available...
Persistent microhematuria and risk of long-term kidney failure in adult patients with immunoglobulin A nephropathy (IgAN) in the United States
This large US study looked at people with a specific kidney disease called IgA nephropathy. It found a link between ongoing blood in the urine and a higher risk of kidney failure....
Anticoagulation for venous thromboembolism in adults with advanced kidney disease: UK Kidney Association clinical practice guideline
This is a new clinical guideline from the UK Kidney Association. It provides advice on treating blood clots in people with advanced kidney disease. The guideline is based on...
Outcomes of pediatric urgent-start peritoneal dialysis: a single-center experience from Jordan
This report describes the experiences of 18 children who started dialysis quickly in Jordan. It was posted on a data repository, not a peer-reviewed journal. The paper details the...
Hyperhomocysteine: a key mediator linking chronic kidney disease to parkinson鈥檚 disease
This review explores the link between kidney disease and Parkinson's disease. It focuses on a substance called homocysteine, which is often high in both conditions. The paper...
The Impact of Ultra-Processed Foods on Chronic Kidney Disease Progression.
This review summarizes studies on ultra-processed foods and kidney health. It finds that eating more of these foods is linked to faster kidney decline. This is a link, not proof of...
Fluid intake adherence and its associated factors in patients receiving maintenance hemodialysis: a cross-sectional study utilizing the COM-B model
This is a preprint about how well dialysis patients follow fluid limits. It has not passed peer review yet. There are no results to report at this time.
A Quasi-Experimental Study to Assess the Effectiveness of Intradialytic Stretching Exercises on Muscle Cramps among the Patients Undergoing Hemodialysis in Selected Hemodialysis Centres of District, Mandi (H.P.)
This study tested if stretching during dialysis reduces muscle cramps. It was a small trial, but the text does not state the exact number of people or duration. The results suggest...
Longitudinal Nutritional and Cardiorenal Changes Among Patients Prescribed a Ketoanalogue-Supplemented Very-Low-Protein Diet in Advanced Nondialysis Chronic Kidney Disease with Chronic Heart Failure: A Retrospective Cohort Study.
This study followed 75 people with late-stage kidney disease and heart failure. They ate a very low-protein diet with special supplements. The researchers tracked their health over...
THE IMPACT OF HIGH-PROTEIN DIETS ON RENAL FUNCTION: A COMPREHENSIVE REVIEW
This review looks at how eating a lot of protein affects the kidneys. It notes that high protein can be hard on people who already have kidney issues. The text does not report new...
Ketoanalogues of Essential Amino Acids in Chronic Kidney Disease: From Biochemical Rationale to Conditions for Clinical Effectiveness
This review explains how a special diet works for kidney disease. It combines very low protein intake with supplements that help the body make needed amino acids. The paper...
M1 macrophage-derived exosomes aggravate diabetic nephropathy by regulating the WTAP/S1PR2 axis.
This study used cells and mice to look at how diabetes damages kidneys. It found that certain cell signals make the damage worse. This was done in a lab and in animals, not in...
Supplementary files: Therapeutic effects of exosome-based therapy in experimental acute kidney injury: A systematic review and meta-analysis
These are extra files for a review on exosome therapy for sudden kidney injury. There are no new results in this file.
The Effect and Mechanism of Bone Marrow Mesenchymal Stem Cell-Derived Exosomes on Renal Injury Induced by Chronic Intermittent Hypoxia
This is a preprint about stem cell treatments for kidney injury. It has not passed peer review yet. There are no results to report at this time.
Early postoperative Galectin-3 for risk stratification of delayed graft function after kidney transplantation
A blood test for a protein called Galectin-3 may help predict if a new kidney will work slowly. This study looked at past records, so it shows a link, not proof of cause. Doctors...
Multimedia decision-support and patient education tool for empowerment in chronic kidney disease and kidney transplantation: development process and prototype testing
Researchers developed a multimedia tool to help patients make decisions about kidney transplants. The paper describes how the tool was built and tested. It aims to reduce...
Treatment Patterns, Disease Management, and Quality of Life in Outpatients with CKD and Decreased eGFR: A Multicenter Prospective Observational Study in Greece.
This study looked at how kidney disease is managed in Greece. It tracked patients over 12 months to see their quality of life. This shows a link between care patterns and patient...
Inflammation across the spectrum of cardiovascular disease: healthcare physician perceptions and practices in six European countries
This study interviewed doctors in six European countries. It explored how they view inflammation in patients with heart disease and kidney disease. The paper reports on physician...