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Association between initial eGFR dip and renal function trajectory in patients with chronic kidney disease initiating SGLT2 inhibitors: a retrospective cohort study

Key takeaways

People with kidney disease who started SGLT2 drugs often see a temporary drop in their kidney filtering rate. This study looked at real-world data to see if that drop predicts long-term kidney health. It found a link between the size of that early dip and how the kidneys functioned later. This shows a connection, not proof of cause, but it helps doctors know the dip is often a good sign.

Who did this work

Satoshi Mochida · Hitomi Hama · Takahiro Abe · Toshio Yamaguchi · Mikio Saito · Yoshihito Kano

Source

Article · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-09-21
https://doi.org/10.1186/s40780-026-00627-6