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Phosphate drives skeletal abnormalities in Klotho-deficient mice

Article D Peer reviewed Preclinical

Key takeaways

This study used mice that lacked a specific protein to model kidney disease. It found that high phosphate levels in the blood caused bone problems. This was done in animals, not people, so it is not yet proven in humans.

Who did this work

Yutaka Miura (Jichi Medical University) · Kazuhiro Shiizaki (Jichi Medical University) · Hiroshi Kurosu (Jichi Medical University) · Makoto Kuro‐o (Jichi Medical University)

Source

Article · OpenAlex, CKD works · 2026-09-19
https://doi.org/10.1038/s41598-026-71006-2