Kidney research, 2026-09-19
New diabetes raises the risk of heart and kidney problems within three years.
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Other reports on blood pressure and drug safety are preliminary and do not yet prove a direct cause for kidney decline.
Today's news focuses on the strong link between new diabetes and serious health problems. A large study showed that many patients faced heart or kidney issues within three years of diagnosis. Other data highlight the role of weight in disease progression. Most other items were background reviews or safety checks without new patient results.
Are SGLT2 inhibitors more effective in specific subgroups of patients with chronic kidney disease (CKD)?
This preprint asks if SGLT2 drugs work better for certain groups of people. It notes that these drugs help people with and without diabetes. It says more research is needed for...
FUNCTIONAL ASSESSMENT OF SMALL FIBER AND AUTONOMIC DYSFUNCTION IN DYSMETABOLIC POLYNEUROPATHIES
This article describes how to test for nerve damage in people with kidney disease. It explains how to check for pain, sweating, and bladder issues. It is a guide for doctors, not a...
Comparative Efficacy and Safety of Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitors in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
This is a preprint of a systematic review and meta-analysis. It compares different SGLT2 drugs for people with type 2 diabetes. It looks at how well they protect the heart and...
What is the efficacy of SGLT2 inhibitors in slowing the progression of chronic kidney disease (CKD)?
This item is a preprint, not a fully reviewed journal article. It states that SGLT2 drugs help slow kidney decline. It says these drugs lower the risk of kidney failure. However,...
Metabolic reprogramming in diabetic panvascular disease: Molecular mechanism and therapeutic strategies
This review explains how diabetes changes how blood vessels use energy. It looks at how high blood sugar and fat levels damage the body's vessels. This damage affects the kidneys,...
Biallelic WDR19 Variants: Systematic Analysis of Genotype-Phenotype Correlations.
This paper reviews 93 cases of a rare genetic condition that affects the kidneys. It looks at how specific gene changes link to health problems. It is a review of case reports, so...
Improving Medication Safety in Chronic Kidney Disease Using Rule-Based and Artificial Intelligence-Based Clinical Decision Support Systems: A Systematic Review of Randomized Controlled Trials.
This review looked at many trials to see if computer tools help doctors pick safe drug doses for kidney patients. It is a meta-analysis, which is the strongest type of evidence....
Office Blood Pressure and Arteriolosclerosis in Biopsy-Proven Glomerulonephritis: Association With Renal Function Decline and Clinical Outcomes.
This study followed 66 adults with a specific type of kidney inflammation. It looked at how blood pressure and blood vessel scarring affect kidney function. It shows a link between...
Finerenone attenuates myocardial fibrosis in myocardial infarction complicated by chronic kidney disease: an integrated study combining network pharmacology, molecular simulations, and in vivo experiments.
This study used computer models and animal tests to look at a drug called finerenone. It examined how the drug affects heart scarring in people with kidney disease. The results are...
HFpEF in Asia-Clinical Characterization and Therapeutic Strategies.
This review discusses heart failure in Asian patients. It notes that kidney disease is a common risk factor in this group. It is a background summary of existing knowledge, not a...
Liraglutide and renal mitochondrial homeostasis: targeting the "metabolism-inflammation-lithogenesis" axis in metabolic syndrome.
This review looks at how a diabetes drug might affect kidney stones. It discusses the role of cell energy systems in kidney health. It is a theoretical review and does not report...
Adverse event reporting signals for SGLT-2 inhibitor-metformin combination therapy: a disproportionality analysis of the FAERS database.
This study checked a large database of reported side effects. It looked at people taking two diabetes drugs together. It shows a link between the drug combo and certain reports,...
[Analysis of related factors for the occurrence of cardiovascular-renal-metabolic syndrome stage 4 in patients with primary aldosteronism].
This study followed 397 patients with a hormone condition called primary aldosteronism. It looked at factors that lead to severe heart and kidney issues. It shows a link between...
High BMI-attributable burden of eight diseases relevant to the CKM framework in China: GBD 2023 estimates and projections to 2050.
This study used global health data to estimate how much high body weight contributes to kidney and heart disease in China. It projects that this burden will grow by 2050. The data...
HbA1c reconsidered: glycated haemoglobin in the era of dynamic erythrocyte glucose metabolism.
This paper reviews how red blood cells handle sugar. It suggests that low oxygen levels can change how much sugar enters these cells. This might affect how accurately a standard...
Three-year incidence and predictors of mortality and microvascular and macrovascular complications after newly diagnosed type 2 diabetes: A population-based cohort study.
This large study followed 5,773 people with new type 2 diabetes for three years. It found that many developed heart, eye, or kidney problems, or died, within that time. The study...
Impact of Organic Foods and Herbal Interventions on Key Biochemical Parameters in Patients with Stage IV Chronic Kidney Disease Over a 9-Month Period
A study followed 100 people with stage 4 kidney disease for nine months. They ate a special organic diet with low protein and salt. The study looked at how this diet affected their...
Organ-specific apoptotic pathways induced by micro- and nanoplastics: a systematic review of in vitro toxicological evidence.
This review looked at how tiny plastic particles affect cells in the lab. It found that these particles can trigger cell death in different organs. This work was done in test...
Integration of microphysiological systems with computational and digital twin modeling for pharmaceutical development: a systematic review.
This review examined how computer models and lab chips are used to test drugs. It discusses using these tools to predict how drugs work in humans. This is a preclinical method, not...
Growth and development following paediatric kidney transplantation: Mechanisms, influencing factors, and clinical management
This is a review article about how children grow after a kidney transplant. It discusses the factors that affect their health. There is no abstract to read, so there are no...
Progression to Insulin Requirement at One Year After Kidney-Alone Transplantation in Insulin-Independent Type 2 Diabetes: Implications for SPK Candidate Selection.
This study followed 132 people who had a kidney transplant and type 2 diabetes. Most of them needed insulin one year later. This is an observational study, so it shows a link but...
Validation of the kidney patient-reported experience measure in Spanish and Catalan.
Researchers tested a survey tool designed to measure how kidney patients feel about their care. They checked if the tool works well in Spanish and Catalan. The study involved 575...