← brief for 2026-09-18 · Regeneration & devices

Cadherin-11 and the mechanobiology of the fibrogenic niche

Key takeaways

Researchers found that blocking a protein called cadherin-11 can limit scarring in the kidneys. This was tested in animal models of kidney injury, not in people yet. The protein helps cells generate force, which drives the scarring process. Stopping this process preserved kidney function in the animals. This suggests a new target for future drugs to prevent kidney damage.

Source

Paper · Kidney International · 2026-10-01
https://www.kidney-international.org/article/S0085-2538(26)00630-7/fulltext?rss=yes