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Diosmetin Restores Endoplasmic Reticulum Homeostasis to Ameliorate Podocyte Injury in Diabetic Kidney Disease by Targeting DNAJC3.

Key takeaways

Diosmetin is a natural plant compound found in citrus fruits. Researchers damaged podocytes, the kidney's filter cells, with high sugar and fat in the lab to mimic diabetic kidney disease. They report that diosmetin helped the cells recover by acting on a protein called DNAJC3, which helps cells handle stress. This was in lab cells, not people yet, so it does not show that diosmetin or citrus supplements help human kidneys.

Who did this work

Zhang T · Zhao N · Liu T · Gao Y · Di Z · Gao Y · Ji Y · Lv S · Xie Q · Ma J · Cui H

Source

Article · PubMed, Climate, heat and the kidney · 2026
https://pubmed.ncbi.nlm.nih.gov/42750101/