← brief for 2026-09-14 · Slowing decline

Disruption of cellular iron homeostasis by SRPX2-IRP1 interaction aggravates renal fibrosis in chronic kidney disease

Paper D Peer reviewed Preclinical

Key takeaways

In test tubes and mice, a protein called SRPX2 binds to iron-handling proteins and worsens kidney scarring. This was not tested in people — it is early lab work that may lead to future drugs.

Who did this work

Peiran Yin · Lumiao Chen · Mengyang Ding · Zhaonan Wei · Anran Huo · Yinfang Wang · Mengjun Xie · 张虎 · Yuan Qin · Haozhe Ding · Ying Lu · Yan Shi

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-09-14
https://doi.org/10.1038/s41418-026-01868-6