← brief for 2026-09-14 · Regeneration & devices

CDK4/6 Inhibitor Abemaciclib Arrests and Reverses Kidney Cyst Progression in Preclinical Models of Autosomal Dominant Polycystic Kidney Disease.

Key takeaways

In test tubes and mice with inherited kidney cysts, a cancer drug called abemaciclib stopped cysts from growing and even reduced them by targeting a protein involved in cell division. This drug is used for breast cancer, but it has not been tested in people with kidney cysts yet — so its safety and effect in humans are unknown.

Who did this work

Cao Y · Sun X · Huang Y · Chen C · Ji B · Chen R · Li Y · Liang Y · Aghevli A · Yang N · Patel V · Harris P

Source

Article · PubMed, fibrosis reversal · 2026 Sep 14
https://pubmed.ncbi.nlm.nih.gov/42735034/