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Associations of Growth Differentiation Factor 15 in Chronic Kidney Disease.

Article C Peer reviewed Observational

Key takeaways

GDF-15 is a protein in the blood that dampens appetite. Researchers measured it in 2,996 people with kidney disease who were not on dialysis, then scored their appetite with a questionnaire and checked their grip strength and estimated muscle mass. Higher levels of this protein went along with poorer appetite and weaker muscles. This is an observational study, so it shows a link, not proof that the protein causes the appetite loss.

Who did this work

McDonnell T · Hayward S · Vuilleumier N · Saleem MA · Kalra PA · Taal MW

Source

Article · PubMed, CKD severity and reversal · 2026 Jul 30
https://pubmed.ncbi.nlm.nih.gov/42733545/