← brief for 2026-09-12 · Slowing decline

Paediatric proteomic signatures of cardiometabolic disease-associated traits predict adult disease outcomes.

Key takeaways

Researchers measured blood proteins in 273 Hispanic and Latino children and teens, average age about 13, and matched them to 25 early signs of trouble in the liver, body fat, blood vessels and blood sugar. Those signs belong to a cluster doctors call cardiovascular-kidney-metabolic disease, which can later include kidney damage. The study shows a link between childhood protein patterns and adult disease risk, not proof that the proteins cause it. It did not measure kidney filtering rate (eGFR) or protein in the urine, so the kidney part of that link is still indirect.

Who did this work

Landman JM · Highland HM · Perry AS · Howard AG · Sheng Q · Lorenz A · Palmer AB · Zhao S · Zhu W · Zhang X · Buchanan VL · Frankel EG

Source

Article · PubMed, the drug frontier · 2026 Sep 11
https://pubmed.ncbi.nlm.nih.gov/42728365/