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Reciprocal mediation of immuno-inflammation and insulin resistance in the risk of chronic kidney disease among patients with coronary artery disease: insights from neutrophil-to-lymphocyte ratio and triglyceride-glucose index

Key takeaways

In people with clogged heart arteries, researchers checked two cheap blood markers: one for inflammation, based on the ratio of two white blood cell types, and one for insulin resistance, based on blood fat and blood sugar. Higher levels on both tracked with a higher chance of having chronic kidney disease, and each one seemed to carry part of the other's effect. That fits the idea that inflammation and blood sugar problems feed each other and wear on the kidneys. This is an observational study, so it shows a link, not proof that either marker causes kidney damage.

Who did this work

Xiaohong Chen (University of Electronic Science and Technology of China) · Min Wang (University of Electronic Science and Technology of China) · Bitao Wu (University of Electronic Science and Technology of China) · Wenqiang Jiang (University of Electronic Science and Technology of China) · Qiang Yang (University of Electronic Science and Technology of China) · Jie Tang (University of Electronic Science and Technology of China) · Pei Yang (University of Electronic Science and Technology of China) · Yuwei Yang (University of Electronic Science and Technology of China)

Source

Paper · OpenAlex, CKD works · 2026-09-09
https://doi.org/10.3389/fimmu.2026.1937248