← brief for 2026-09-10 · Slowing decline

Personalized Sequential Nephron Blockade for Diuretic Resistance in Acute Decompensated Heart Failure: A Narrative Review for the Cardiorenal Clinician

Key takeaways

Doctors wrote a guide on what to do when one water pill stops clearing fluid in people with heart failure. The idea is to use several drugs together, each one blocking salt and water at a different point along the kidney's filtering tube. This matters because heart failure and kidney disease often go together, and trapped fluid is hard to treat. It is a summary of other people's work, so it reports no new results of its own.

Who did this work

Guido Gembillo (University of Messina) · Concetto Sessa (Ospedale Maggiore) · Luca Zanoli (University of Catania) · Luca Visconti (Ospedale Vincenzo Cervello) · Maria Federica Ricca (University of Messina) · Lorenzo Lo Cicero (University of Messina) · Andrea Corsonello (Istituto Nazionale di Riposo e Cura per Anziani) · Salvatore Petrina (AOL (United States)) · Antonino Nicosia (AOL (United States)) · Luca Soraci (Istituto Nazionale di Riposo e Cura per Anziani) · Giuseppe Fede (Ospedale Maggiore) · Guglielmo Piccione (Ospedale Maggiore)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-09-09
https://doi.org/10.3390/jpm16090466