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Latent histopathological activation of the renin–angiotensin–aldosterone system in children with low birth weight

Key takeaways

Researchers examined kidney tissue from children who were born small, at a low birth weight. They found quiet signs that the hormone system controlling blood pressure and salt, called the renin-angiotensin-aldosterone system, was switched on. That system is the target of common blood pressure drugs. This shows a link, not proof that low birth weight causes the change, and it is a preprint that other scientists have not checked yet.

Who did this work

Shingo Ishimori (Kobe University) · Shinya Ishiko (Takatsuki General Hospital) · Junya Fujimura (Kagawa Prefectural Central Hospital) · Asahi Yamamoto (Kobe Institute Of Computing) · Shuhei Aoyama (Kobe Institute Of Computing) · Yuka Kimura (Kobe Institute Of Computing) · Yuta Inoki (Kobe Institute Of Computing) · Miki Matsui (Hyogo University) · Tomoko Horinouchi (Kobe Institute Of Computing) · Tomohiko Yamamura (Kobe Institute Of Computing) · Nana Sakakibara (Kobe Institute Of Computing) · China Nagano (Kobe Institute Of Computing)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-09-10
https://doi.org/10.21203/rs.3.rs-10774896/v1