← brief for 2026-09-10 · Mind-body

eNOS Uncoupling, Shear-Stress Tolerance, and the Two-Threshold Model of Post-Exertional Malaise in Long COVID: A Mechanistic Hypothesis With Implications for Physiotherapy and Recovery Protocols.

Key takeaways

This paper puts forward an idea to be tested, not a study with data. The authors propose that in some people with long COVID, the crash that follows exertion comes from a fault in how small blood vessels make nitric oxide, the signal that tells vessels to relax. They lay out predictions and blood tests that could prove them wrong. No patients were studied, so there are no results yet, and none of it touches kidney disease.

Who did this work

Karipidis YK (Independent Researcher, Giannitsa, Greece.) · Karipidis KY (Department of Physiotherapy, Faculty of Health Sciences, International Hellenic University Alexander Campus, Thessaloniki, Greece.)

Source

Paper · Europe PMC, CKD mind-body · 2026-08-01
https://doi.org/10.1111/micc.70082