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Addressing the Pathophysiology of Venous Thrombosis and Chronic Kidney Disease in Sickle Cell Trait Using a Mouse Model

Key takeaways

Researchers built a mouse model to study why sickle cell trait is tied to blood clots in veins and to long-term kidney damage. Sickle cell trait means carrying one copy of the sickle gene, which usually causes few problems. The work was done in mice, not people, so it cannot say what happens in humans. It is early lab work aimed at explaining the cause.

Who did this work

Nigel S. Key (University of North Carolina at Chapel Hill) · Vimal K. Derebail (University of North Carolina at Chapel Hill) · Małgorzata Kasztan · Fatima Trebak (University of North Carolina at Chapel Hill) · Izabela J. Pawlinski (University of North Carolina at Chapel Hill) · Rafał Pawliński (University of North Carolina at Chapel Hill) · Michael W. Henderson (University of North Carolina at Chapel Hill) · Patrick Ellsworth (University of North Carolina at Chapel Hill) · Dougald M. Monroe (University of North Carolina at Chapel Hill) · Karnsasin Seanoon (University of North Carolina at Chapel Hill) · Chatphatai Moonla (University of North Carolina at Chapel Hill) · Steven P. Grover (University of North Carolina at Chapel Hill)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-09-09
https://doi.org/10.17615/jv36-ab51