← brief for 2026-09-08 · Nutrition & lifestyle

Nigella sativa extract modulates Nrf2-related and renal transporter expression in a rat model of cisplatin-induced acute kidney injury

Paper D Peer reviewed Preclinical

Key takeaways

Rats were given a chemotherapy drug, cisplatin, that damages kidneys, then treated with black seed extract (Nigella sativa). The extract shifted the activity of genes that control the kidney's antioxidant defenses and its transport proteins. This was done in rats, not people, so it does not tell us whether the supplement helps or harms a person with kidney disease. Herbal extracts can also interact with kidney drugs, so this is a lab finding only.

Who did this work

Reza Alipanah-Moghadam · Shakila Kebari-Seddig · Sanaz Abbaszadeh · Narges Soozangar · Farhad Jeddi · Ramin Salimnejad · Bahman Bashardoust · Ali Nemati

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-09-07
https://doi.org/10.1038/s41598-026-70239-5