← brief for 2026-09-08 · Regeneration & devices

Kidney-on-Chip and Organoid Models: Harnessing Mechanical Forces for Translational Kidney Biology.

Key takeaways

This is a review of lab-grown kidney models: tiny kidney tissues called organoids, and chips that mimic the physical push and pull of fluid inside a real kidney. New United States policy is pushing drug testing away from animals and toward these human-based models. The article argues that adding realistic mechanical forces makes these models behave more like living kidneys. No experiment is reported, so there are no results yet, and nothing here has been tested in people.

Who did this work

Daily A · Anandakrishnan N · Haydak J · Himmelfarb J · Azeloglu EU

Source

Article · PubMed, organoids & devices · 2026 Sep 8
https://pubmed.ncbi.nlm.nih.gov/42709582/