← brief for 2026-09-08 · Slowing decline

Bruceine A attenuates renal tubulointerstitial fibrosis by inhibiting the Wnt7a/PI3K/AKT pathway

Paper D Peer reviewed Preclinical

Key takeaways

Bruceine A is a compound from a plant used in traditional medicine. In this lab study it reduced scarring in kidney tissue, the process that slowly hardens the kidney and cuts its filtering power. It seemed to work by blocking a chemical signalling chain inside kidney cells called Wnt7a/PI3K/AKT. This was done in animals or cells, not people, so there is no way to know yet if it helps a person.

Who did this work

Shuangyu Li (Anhui Medical University) · Renqing Wang (Anhui Medical University) · Tong Wang (Anhui Medical University) · Wenyan Zhang (Anhui Medical University) · Shengchun Xu (Anhui Medical University) · Zhenhua Ren (Anhui Medical University) · Renfei Luo (Anhui Medical University)

Source

Paper · OpenAlex, CKD works · 2026-09-07
https://doi.org/10.3389/fphar.2026.1865261