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Urinary Tissue Inhibitor of Metalloproteinases-2 and Insulin Like Growth Factor Binding Protein-7 as Early Markers of Cardiorenal Syndrome Type -1 in Patients Hospitalized with Acute Heart Failure

Key takeaways

Researchers measured two proteins in the urine, TIMP-2 and IGFBP7, in people admitted to hospital with sudden heart failure. Both proteins rise early when the kidneys are under stress, so the aim was to catch kidney injury sooner than standard blood tests do. This was an observational study, so it shows the markers track with kidney injury, not that acting on them helps anyone. It was posted to a public file repository, so it has not been through journal peer review.

Who did this work

H M Mohiuddin Alamgir (Dhaka Medical College and Hospital)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-09-05
https://doi.org/10.5281/zenodo.22327940