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Serum C4/C3 ratio at disease onset predicts end-stage renal disease in microscopic polyangiitis: the multicentre REVEAL cohort

Key takeaways

Microscopic polyangiitis is a disease where the immune system attacks small blood vessels, often including the ones in the kidneys. Researchers followed patients at several hospitals and found that the ratio of two immune proteins in the blood, C4 and C3, measured when the disease first showed up, lined up with who later reached kidney failure. This is an observational study, so it shows a link, not proof that the ratio causes the damage. The listing did not include the number of patients or how strong the link was.

Who did this work

Mayu Shiomi (Osaka Metropolitan University) · Ryu Watanabe (Osaka Metropolitan University) · Muneyuki Hatta (Osaka Metropolitan University) · Shogo Matsuda (Osaka University of Pharmaceutical Sciences) · Takuya Kotani (Osaka University of Pharmaceutical Sciences) · Ayana Okazaki (Osaka University of Pharmaceutical Sciences) · Yuichi Masuda (Osaka University of Pharmaceutical Sciences) · Mikihito Shoji (Kyoto University) · Keiichiro Kadoba (Kyoto University) · Ryosuke Hiwa (Kyoto University) · Kaho Jo (Yodogawa Christian Hospital) · Youhei Fujiki (Yodogawa Christian Hospital)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-09-05
https://doi.org/10.1038/s41598-026-70439-z