← brief for 2026-09-06 · Nutrition & lifestyle

Association between vitamin D deficiency and chronic kidney disease progression: A GRADE-based dose-response systematic review and meta-analysis.

Article C Peer reviewed Observational

Key takeaways

Researchers pooled observational studies published between 1990 and 2024 that measured vitamin D in the blood and then tracked whether kidney disease got worse. People with lower vitamin D were more likely to see their disease progress, and the link got stronger as levels dropped further. Every study inside this review was observational, so this shows a link, not proof that low vitamin D causes the decline. Sick kidneys also make it harder for the body to activate vitamin D, so cause and effect can run either way.

Who did this work

Mojtahedi SY · Sedighiyan M · Pourpashang P

Source

Article · PubMed, CKD progression · 2026 Sep 4
https://pubmed.ncbi.nlm.nih.gov/42700010/