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Tonsillar Tfh cells contribute to the pathogenesis of IgA nephropathy in collaboration with memory B cells

Key takeaways

IgA nephropathy is a kidney disease where a protein called IgA builds up in the kidney's filters and damages them. This lab study looked at immune cells taken from tonsils and found two types working together to make the harmful antibodies. That helps explain why removing the tonsils sometimes helps people with this disease. This was cell and tissue work, not a treatment tested in patients.

Who did this work

Taiki Sugaya (Sapporo Medical University) · Ippei Ikegami (Sapporo Medical University) · Ryuta Kamekura (Sapporo Medical University) · Akira Yorozu (Sapporo Medical University) · Hiroshi Sakamoto (Sapporo Medical University) · Ayumi Tatekoshi (Sapporo Medical University) · Masanobu Tanemoto (Sapporo Medical University) · Takeshi Ohyu (Sapporo Medical University) · Shotaro Shirato (Sapporo Medical University) · Ken-ichi Takano (Sapporo Medical University) · Shingo Ichimiya (Sapporo Medical University)

Source

Paper · OpenAlex, Kidney disease concept sweep (verified C2778653478) · 2026-09-03
https://doi.org/10.3389/fimmu.2026.1848238